{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:54:38Z","timestamp":1781502878418,"version":"3.54.1"},"reference-count":65,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2022QE275"],"award-info":[{"award-number":["2022QE275"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Osteoarthritis (OA), a prevalent degenerative joint disorder characterized by articular cartilage deterioration, represents a major global health challenge. Recent studies highlight the pivotal role of reactive oxygen species (ROS)\u2010mediated ferroptosis in OA pathogenesis. Here, we report a microenvironment\u2010adaptive hydrogel system based on 2D vanadium nitride (V\n                    <jats:sub>2<\/jats:sub>\n                    N) MXene nanoenzyme (hereafter denoted as\u00a0V\n                    <jats:sub>2<\/jats:sub>\n                    N MXenzyme@Gel). This system features a dual\u2010crosslinked network that optimally balances between mechanical robustness and flexibility. Crucially, the V\n                    <jats:sub>2<\/jats:sub>\n                    N MXenzyme establishes a self\u2010sustaining \u201ccapture\u2010conversion\u2010recycling\u201d catalytic cycle, mimicking both superoxide dismutase (SOD) and catalase (CAT) activities.\u00a0The cycle not only neutralizes detrimental ROS into water (H\n                    <jats:sub>2<\/jats:sub>\n                    O) and oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    ) but also generates nitric oxide (NO), collectively alleviating oxidative damage. Mechanistically,\u00a0V\n                    <jats:sub>2<\/jats:sub>\n                    N MXenzyme@Gel\u00a0effectively scavenges ROS, attenuates oxidative stress, and suppresses ferroptosis by regulating the Hspa5\/GPX4 axis, while concurrently restoring the metabolic homeostasis of chondrocyte extracellular matrix (ECM). Meanwhile, intra\u2010articular administration of\u00a0V\n                    <jats:sub>2<\/jats:sub>\n                    N MXenzyme@Gel\u00a0significantly attenuates cartilage degradation and inflammation levels\u00a0in OA rats. Collectively, our work presents a V\n                    <jats:sub>2<\/jats:sub>\n                    N MXenzyme@Gel with dual capabilities for ROS elimination and ferroptosis blockade, demonstrating its efficacy in arresting OA progression and proposing a novel precision strategy for managing chronic joint diseases.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504967","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:48:10Z","timestamp":1771663690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microenvironment\u2010Adaptive Smart Hydrogel with 2D Vanadium Nitride MXenzyme Rescues Osteoarthritis via Coordinated ROS Scavenging and Hspa5\/GPX4 Axis\u2010Mediated Ferroptosis Suppression"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8357-9678","authenticated-orcid":false,"given":"Yanlin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Qilu Hospital Shandong University  Jinan Shandong P. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwen","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Qilu Hospital Shandong University  Jinan Shandong P. R. China"},{"name":"Qilu Hospital of Shandong University  Jinan Shandong P. R. China"},{"name":"Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Qilu Hospital Shandong University  Jinan Shandong P. R. China"},{"name":"Qilu Hospital of Shandong University  Jinan Shandong P. R. China"},{"name":"Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Li","sequence":"additional","affiliation":[{"name":"Cheeloo College of Medicine Shandong University  Jinan Shandong P. R. 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