{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:48:46Z","timestamp":1791254926169,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52302357"],"award-info":[{"award-number":["52302357"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Oxidative stress therapy holds great potential owing to its noninvasive nature and high selectivity; however, its efficacy is largely limited by the hypoxic and antioxidative tumor microenvironment (TME). Herein, Ru\u2010doped zinc peroxide (RZO) hollow nanospheres are developed for amplified tumor oxidative stress therapy under US activation. Ru doping optimizes the band structure of ZnO\n                    <jats:sub>2<\/jats:sub>\n                    and enhances charge separation efficiency. Under US activation, the piezoelectric polarization of RZO promotes the generation of superoxide (\u00b7O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) and hydroxyl radicals (\u00b7OH), while the in situ\u2013produced H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    under mildly acidic conditions facilitates \u00b7OH formation. These synergistic processes induce a cascade of \u201creactive oxygen species (ROS) storms,\u201d leading to mitochondrial damage and apoptosis. In vitro studies demonstrate that RZO\u2010mediated oxidative stress therapy effectively suppresses both 4T1 breast adenocarcinoma and SCC\u20109 squamous carcinoma cells, while in vivo experiments confirm remarkable tumor inhibition with negligible systemic toxicity. This work proposes a universal and controllable amplification strategy, offering a promising nanoplatform for precise tumor oxidative stress therapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504973","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T14:03:53Z","timestamp":1766412233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ultrasound\u2010Driven Hollow Nanospheres for Amplified Tumor Oxidative Stress Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Qiurong","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Gannan Medical University  Ganzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[{"name":"Ganzhou Women and Children's Health Care Hospital  Ganzhou 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