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Herein, we report a multifunctional porous sponge constructed from chitosan (CS), sodium alginate (SA), and carboxymethyl cellulose (CMC) via a polyelectrolyte coupling strategy. By optimizing the CS\/SA ratio and introducing CMC as a hydrogen\u2010bonding reinforcement component, the resulting sponge exhibits an interconnected porous architecture, favorable mechanical resilience under wet conditions, and rapid fluid uptake. The synergistic integration of cationic CS and anionic polysaccharides enables strong blood cell and protein interactions, promoting efficient clot formation without external compression. Meanwhile, the intrinsic antibacterial activity arises from CS\u2010induced bacterial membrane disruption combined with microenvironment modulation by the polysaccharide network. In vivo evaluation using a mouse liver hemorrhage model demonstrates rapid bleeding suppression and significantly reduced blood loss compared with conventional gauze, together with favorable tissue compatibility and accelerated wound healing behavior. This work provides a sustainable and facile strategy for designing biomass\u2010derived hemostatic sponges that integrate rapid intrinsic hemostasis, antibacterial functionality, and biocompatibility, offering a promising platform for next\u2010generation wound management materials.<\/jats:p>","DOI":"10.1002\/adhm.202504977","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:13:46Z","timestamp":1773303226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Biomass\u2010Derived Composite Sponges with Synergistic Hemostatic and Antibacterial Efficacy for Emergency Wound Care"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6813-1005","authenticated-orcid":false,"given":"Meichun","family":"Ding","sequence":"first","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Public Health and Health Management Shandong First Medical University &amp; 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Institute of Materia Medica Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanyu","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences &amp; Institute of Materia Medica Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences &amp; Institute of Materia Medica Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0343-3699","authenticated-orcid":false,"given":"Chenwei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemistry and Pharmaceutical Engineering Shandong First Medical University &amp; 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