{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:58:48Z","timestamp":1787320728824,"version":"build-2736575974"},"reference-count":130,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UG3\/UH3TR002884"],"award-info":[{"award-number":["UG3\/UH3TR002884"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["U18TR003807"],"award-info":[{"award-number":["U18TR003807"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL149637"],"award-info":[{"award-number":["T32HL149637"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA016058"],"award-info":[{"award-number":["P30CA016058"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["1285320"],"award-info":[{"award-number":["1285320"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Invasive lobular carcinoma (ILC) accounts for 10\u201315% of breast cancers. Despite favorable responses to anti\u2010estrogen therapy, the dissemination of cancer cells and resistance to therapies are significant risks for patients with ILC. Late recurrences are prevalent in ILC, suggesting that disseminated tumor cell (DTC) dormancy may be a mechanism preceding their late overt growth into metastatic lesions. Herein, we investigated the relationship between anti\u2010estrogen resistance and dormancy through multidimensional, micro\u2010compartmentalized in vitro models. The bioengineered platforms recapitulated the morphological characteristics of ILC and highlighted its distinction from invasive ductal carcinoma (IDC). Inducing a reversible dormant phenotype revealed epigenetic changes and enhanced chemical and mechanical sensing of anti\u2010estrogen\u2010resistant ILC cells to the substrate surface, with p27\n                    <jats:sup>Kip1<\/jats:sup>\n                    signaling playing a central role. We propose this platform as a high\u2010throughput method for investigating ILC dormancy and its manifestation using a simplified, expedited approach.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202504981","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:42:15Z","timestamp":1779252135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidimensional Cellular Micro\u2010Compartments to Model Invasive Lobular Carcinoma Dormancy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5633-5887","authenticated-orcid":false,"given":"Xilal Y.","family":"Rima","sequence":"first","affiliation":[{"name":"William G. Lowrie Department of Chemical and Biomolecular Engineering The Ohio State University  Columbus Ohio USA"},{"name":"Diabetes and Metabolism Research Center The Ohio State University Wexner Medical Center  Columbus Ohio USA"},{"name":"Department of Internal Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarmila","family":"Majumder","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"},{"name":"Comprehensive Cancer Center The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya S.","family":"Patel","sequence":"additional","affiliation":[{"name":"William G. Lowrie Department of Chemical and Biomolecular Engineering The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Hu","sequence":"additional","affiliation":[{"name":"William G. Lowrie Department of Chemical and Biomolecular Engineering The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"William G. Lowrie Department of Chemical and Biomolecular Engineering The Ohio State University  Columbus Ohio USA"},{"name":"Center for Clinical and Translational Research Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"William G. Lowrie Department of Chemical and Biomolecular Engineering The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Truc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"William G. Lowrie Department of Chemical and Biomolecular Engineering The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Doon\u2010Ralls","sequence":"additional","affiliation":[{"name":"William G. Lowrie Department of Chemical and Biomolecular Engineering The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiranth K.","family":"Nagaraj","sequence":"additional","affiliation":[{"name":"William G. Lowrie Department of Chemical and Biomolecular Engineering The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangesh D.","family":"Hade","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Research Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setty M.","family":"Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Research Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eswar","family":"Shankar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"},{"name":"Comprehensive Cancer Center The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Stover","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"},{"name":"Comprehensive Cancer Center The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhuvaneswari","family":"Ramaswamy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The Ohio State University Wexner Medical Center  Columbus Ohio USA"},{"name":"Comprehensive Cancer Center The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8271-8205","authenticated-orcid":false,"given":"Eduardo","family":"Re\u00e1tegui","sequence":"additional","affiliation":[{"name":"William G. Lowrie Department of Chemical and Biomolecular Engineering The Ohio State University  Columbus Ohio USA"},{"name":"Comprehensive Cancer Center The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.70043"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010020\u201001195\u20104"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902233200802"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703643"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3793"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2256"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:BREA.0000004377.12288.3c"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010020\u20100263\u20100"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701830"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13734"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.05.006"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4137\/CPath.S31563"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754\u20109485.12080"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.0334"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.09.033"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244\u2010021\u201001120\u20104"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.11156"},{"key":"e_1_2_10_19_1","first-page":"637","article-title":"Metastatic Patterns of Invasive Lobular versus Invasive Ductal Carcinoma of the Breast","volume":"114","author":"Borst M. J.","year":"1993","journal-title":"Surgery"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac157"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010016\u20102275\u20104"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071718"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.03.014"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.09.26.559548"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215396"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202013180"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523\u2010024\u201000661\u20103"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI175824"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfae122"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00037"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13036\u2010018\u20100137\u20100"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13036\u2010018\u20100120\u20109"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adl0165"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw6171"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1142\/s2339547817500078"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201017\u20103719"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adr3997"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.02.039"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.04.022"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/c6lc01193d"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507681102"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sna.2021.113229"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.5126608"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1lc01053k"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201504154"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000519"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma00148a034"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328219895738"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009447"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2415028122"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103834108"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010025\u201007788\u20106"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102559.1982.tb02712.x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201001170\u20107"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.147.1.89"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010021\u201000291\u20109"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u20107\u201055"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153411"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.52.34710"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3465"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz4157"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25972"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1547001"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15207"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201028076\u20103"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7170"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058\u2010018\u20101049\u20100"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.11.020"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010022\u201000263\u20103"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20104827(76)90336\u20100"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010021\u201000404\u20103"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007554\u20102"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E22\u201002\u20100070"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12572"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508\u2010023\u201002162\u2010y"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804612200"},{"key":"e_1_2_10_77_1","first-page":"627","article-title":"Differential Isolation of Normal Luminal Mammary Epithelial Cells and Breast Cancer Cells from Primary and Metastatic Sites Using Selective Media","volume":"53","author":"Ethier S. P.","year":"1993","journal-title":"Cancer Research"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/53.3.661"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601790"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201032523\u20106"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108656"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009104\u20101"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2014.09.004"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201010964\u2010w"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121477"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201034165\u20100"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10137"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.274027.115"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.REV119.007963"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3458"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201005\u20103092"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878\u20100261.12372"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.419"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2011.07.007"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16784"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2018.07.003"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.03.007"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3277"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010017\u20100075\u20101"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812029106"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(02)00824\u20103"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.63743"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500427"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820\u2010024\u201001421\u20105"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010021\u201001853\u20108"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.226"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2767"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021109288"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1596"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101393"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.11.010"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.11.014"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201019\u20102415"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao4227"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005043\u2010y"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201004070\u20106"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010018\u20100267\u20100"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010025\u201003877\u20103"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201021\u20101407"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201019\u20103607"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201011716\u20106"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010025\u201003763\u2010y"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.6"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.010"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.12.013"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010018\u20100104\u20106"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202502146"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010018\u20100193\u20102"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw9021"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023120\u20100"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12258"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504981","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202504981","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202504981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:59:25Z","timestamp":1787317165000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202504981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":130,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/adhm.202504981"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202504981","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.64898\/2026.01.09.698501","asserted-by":"object"}]},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"assertion":[{"value":"2025-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e04981"}}