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Oral propranolol is effective but limited by systemic side effects and resistance. To overcome these challenges, we developed a novel barbed microneedle (MN) system for depth\u2010specific dual\u2010drug delivery. Bleomycin (BLM) is loaded in the needle tips for deep ablation, while timolol (TM) is incorporated in the base hydrogel for superficial vasoconstriction, enabling synergistic therapy (TM\u2010BLM@MN). The barbed structure secured prolonged retention in vivo. In vitro, the TM\u2010BLM@MN significantly inhibited hemangioma stem cell proliferation, migration, and tube formation. In vivo, treatment of TM\u2010BLM@MN achieved a 1.93\u2010fold greater reduction in tumor volume compared to controls and markedly suppressed pathological angiogenesis by histology. TM\u2010BLM@MN as a minimally invasive platform demonstrates high efficacy for thick IH and holds strong potential for clinical translation and home\u2010based therapy.<\/jats:p>","DOI":"10.1002\/adhm.202505039","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:50:51Z","timestamp":1770270651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Barbed Microneedle Array\u2010Mediated Dual\u2010Drug Delivery for Thick Infantile Hemangiomas"],"prefix":"10.1002","volume":"15","author":[{"given":"Pei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue Engineering Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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