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This process is driven by the overexpression of vascular endothelial growth factor (VEGF) and its interaction with the VEGF receptor\u20102 (VEGFR\u20102), stimulating angiogenesis. The oxidative stress induced by reactive oxygen species accumulation further promotes the growth of new blood vessels, exacerbating the condition. Therefore, developing a multifaceted treatment capable of inhibiting the VEGF\u2010VEGFR\u20102 interaction and mitigating oxidative stress is critical. Catechin (Ch), known for its antioxidant, anti\u2010inflammatory, and anti\u2010angiogenic properties, faces limitations in medical use due to its poor bioactivities, low solubility in water, and instability. 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