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However, many conventional hemostatic agents fail to sequester fibrin and assemble a stable clot, which limits their effectiveness in emergency care. In this study, hydroxyapatite (HAp)\u2010doped gelatin microspheres (GHMPs\u201010) are developed to enhance hemostasis in high\u2010pressure hemorrhage by accelerating the coagulation process. Initially, the surface\u2010exposed HAp domains of GHMPs\u201010 facilitates the rapid recruitment of fibrinogen and its subsequent assembly into a robust network, enhancing the entrapment of platelets and erythrocytes to stabilize the thrombus. In addition, hydrophilic groups in the gelatin matrix enable rapid fluid uptake and microsphere expansion (\u2248718%). This concentrates local coagulation factors and platelets and accelerates fibrin network formation, while the expanded microspheres mechanically occlude the injury site. Functionally, GHMPs\u201010 withstood \u2248191.5\u00a0mmHg in burst\u2010pressure testing and, across multiple animal models, achieved shorter hemostasis times with lower blood loss than commercial powders. By rapidly initiating coagulation and concentrating blood components to form a mechanically robust hydrogel clot, these fibrinogen\u2010capturing microspheres emerge as a highly promising candidate for rapid hemostasis, with potential for clinical translation.<\/jats:p>","DOI":"10.1002\/adhm.202505052","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:56:34Z","timestamp":1766123794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioinspired Fibrin\u2010Trapping Microspheres Enable Supra\u2010Physiological Clot Formation Under High\u2010Pressure Hemostasis"],"prefix":"10.1002","volume":"15","author":[{"given":"Yuanyuan","family":"Ding","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Biomaterials Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Sichuan University West China Hospital  37 Guoxue Lane Wuhou District Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0268-6598","authenticated-orcid":false,"given":"Ju\u2010E","family":"Cun","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"He","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Biomaterials Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010021\u201000769\u2010y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.01.027"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010bioeng\u2010012521\u2010101942"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c01015"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.12.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308171"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.06.023"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202305222"},{"key":"e_1_2_8_10_1","first-page":"47","volume-title":"Hemostasis and Anticoagulation Therapy\u201d, in Vascular Diseases for the Non\u2010Specialist. 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