{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:18:44Z","timestamp":1786976324430,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100639;82200630;81970526."],"award-info":[{"award-number":["82100639;82200630;81970526."]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Portal hypertension (PHT), a life\u2010threatening complication of chronic liver disease, is driven by increased hepatic vascular resistance, with liver sinusoidal endothelial cell (LSEC) dysfunction and impaired nitric oxide (NO) signaling as key contributors. This study synthesized spermidine\u2010based carbon quantum dots (ST\u2010CQDs) and investigated their therapeutic effects on PHT. ST\u2010CQDs (average size 2.12\u00a0nm) exhibited good biocompatibility and effectively induced NO production in human immortalized LSECs (hiLSECs) by upregulating endothelial NO synthase (eNOS). In BDL and CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2010induced PHT rat models, intravenous ST\u2010CQDs reduced portal pressure by decreasing intrahepatic vascular resistance, reversed LSEC capillarization, inhibited hepatic stellate cell activation and liver fibrosis, and alleviated liver inflammation\u2014without altering systemic hemodynamics or causing organ toxicity. In vitro, ST\u2010CQDs reversed lipopolysaccharide\u2010induced LSEC dysfunction by restoring eNOS expression and NO release. These findings demonstrate ST\u2010CQDs as a potential therapeutic agent for PHT via targeting LSEC\u2010derived NO signaling.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505055","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T11:57:38Z","timestamp":1769774258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spermidine\u2010Based Carbon Quantum Dots Alleviate Liver Sinusoidal Endothelial Dysfunction by Inducing LSEC\u2010Derived NO to Ameliorate Hepatic Fibrosis and Portal Hypertension"],"prefix":"10.1002","volume":"15","author":[{"given":"Jin\u2010Bo","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of General Surgery Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine No. 639 Zhizaoju Road, Huangpu District Shanghai 200011 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