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We engineered a reactive oxygen species (ROS)\u2010responsive, macrophage\u2010membrane\u2010camouflaged quercetin nano\u2010therapy (MM@PCD@QNPs) to enhance ovarian delivery and mitigate toxicity. The core comprises a pinacol phenylboronate\u2010dextran conjugate that encapsulates quercetin and undergoes ROS\u2010triggered release; a surface M0 macrophage membrane confers immune evasion and lesion tropism via retained proteins (e.g., CD11b and CD47\u2010SIRP\u03b1). MM@PCD@QNPs displayed nanoscale dimensions and stability (133.63\u00a0\u00b1 14.60\u00a0nm; \u221233.13 \u00b1 1.52\u00a0mV) and released drug under elevated ROS. In DHT\u2010injured granulosa cells and a DHEA\u2010induced PCOS mouse model, the formulation promoted granulosa cell proliferation, suppressed apoptosis, reduced ROS, and preferentially accumulated in ovaries, with negligible in vitro and in vivo toxicity. Transcriptomics and validation implicate activation of the MAPK7\u2010Nrf2\u2010NQO1 axis as a principal mechanism; pharmacologic MAPK7 inhibition abrogated therapeutic effects. By coupling ROS\u2010triggered release with macrophage\u2010mimetic targeting, MM@PCD@QNPs overcome quercetin's low bioavailability and off\u2010target exposure and provide a safe, effective nanoplatform for PCOS therapy.<\/jats:p>","DOI":"10.1002\/adhm.202505171","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:13:43Z","timestamp":1771665223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Macrophage Membrane\u2010Cloaked, ROS\u2010Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome"],"prefix":"10.1002","volume":"15","author":[{"given":"Wenzhu","family":"Li","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center Renmin Hospital of Wuhan University Wuhan University  Wuhan 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