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In this study, we have developed bone\u2010targeting selenium\u2010doped carbon dots conjugated with alendronate (ASCDs) with the dual functionality of suppressing ferroptosis and promoting osteogenesis. In vitro, ASCDs mitigated erastin\u2010induced ferroptosis in osteoblasts and bone\u2010marrow mesenchymal stem cells by activating the system Xc\n                    <jats:sup>\u2212<\/jats:sup>\n                    \u2010GSH\u2010GPX4 antioxidant pathway, which reduced lipid peroxidation and restored mitochondrial function. Furthermore, ASCDs induced ALP activation and mineralized nodule formation under ferroptosis conditions, and enhanced expression of osteogenic markers, including RUNX2, OPN, and OSX. In vivo, ASCDs demonstrated superior efficacy compared to non\u2010targeted selenium\u2010doped carbon dots (SCDs), significantly reversing trabecular bone loss in ovariectomized mice, reducing osteoclast activity, and suppressing ferroptosis in bone tissue. Proteomics and biochemical analyses further validated that ASCDs exert therapeutic effects by rescuing GPX4 expression and redox homeostasis. Such dual\u2010functional carbon dots present a targeted strategy to treat PMOP by concurrently inhibiting ferroptosis and restoring bone formation.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505203","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T06:28:24Z","timestamp":1770186504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bone\u2010Targeting Selenium\u2010Doped Carbon Dot\u2010Based Nanoparticles for Ferroptosis Suppression and Osteogenesis Against Postmenopausal Osteoporosis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6860-9726","authenticated-orcid":false,"given":"Jingcheng","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Hebei Medical University Third Hospital  Shijiazhuang P. R. 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