{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T23:27:15Z","timestamp":1792538835021,"version":"4.5.0"},"reference-count":71,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFB3714400"],"award-info":[{"award-number":["2024YFB3714400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52441409 52474389 52271145 52204388"],"award-info":[{"award-number":["52441409 52474389 52271145 52204388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515010505"],"award-info":[{"award-number":["2025A1515010505"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In order to develop a promising bio\u2010applicable body\u2010centered\u2010cubic multi\u2010principal element alloy (BCC MPEA) with excellent mechanical and biological properties, Tantalum (Ta) was introduced into TiNbZr alloy based on lattice distortion design, and heterogeneous structure was subsequently constructed. The widespread hetero\u2010structured interfaces alter planar slip mode in recrystallized grains (RGs) via emission and multiplication of geometrically necessary dislocations (GNDs), which generate significant heterogeneous deformation induced (HDI) stress effect. Plentiful subgrains and nano\u2010sized dislocation cells in unrecrystallized grains (UGs, i.e., textures) enable extensive dislocation behavior including annihilation, activation and interaction, effectively alleviating stress concentration in RGs and strain gradient across the interfaces. This process results in an optimal balance of yield strength reaching 925.2\u00a0MPa and fracture elongation of 26.1%. In vitro experiments demonstrate that TiNbZr\n                    <jats:sub>0.7<\/jats:sub>\n                    Ta\n                    <jats:sub>0.3<\/jats:sub>\n                    alloy exhibits enhanced cell adhesion, proliferation and osteogenic response compared to TC4 alloy. The remarkable mechanical properties and biocompatibility render it a highly promising candidate for orthopedic implants. This study provides new insights for the design and optimization of biomedical MPEAs with excellent mechanical properties.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505213","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:08:28Z","timestamp":1768813708000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["High\u2010Strength and Ductile TiNbZrTa BCC MPEA With Heterogeneous Microstructure for Orthopedic Implants"],"prefix":"10.1002","volume":"15","author":[{"given":"Shikun","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering, State Key Laboratory of Cemented Carbide Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zili","family":"Xu","sequence":"additional","affiliation":[{"name":"Centre For Translational Medicine Research &amp; Development, Shenzhen Institute of Advanced Technology Chinese Academy of Sciences  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4995-7594","authenticated-orcid":false,"given":"Weidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, State Key Laboratory of Cemented Carbide Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlu","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Dentistry University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, State Key Laboratory of Cemented Carbide Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7668-8428","authenticated-orcid":false,"given":"Yuanchi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Centre For Translational Medicine Research &amp; Development, Shenzhen Institute of Advanced Technology Chinese Academy of Sciences  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingru","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, State Key Laboratory of Cemented Carbide Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, State Key Laboratory of Cemented Carbide Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, State Key Laboratory of Cemented Carbide Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6812-905X","authenticated-orcid":false,"given":"Zhenggang","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, State Key Laboratory of Cemented Carbide Hunan University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202408941"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17981"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actamat.2014.08.026"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2023.171755"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2024.174823"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.corsci.2020.108696"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scriptamat.2016.10.028"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.05.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intermet.2022.107568"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2021.09.034"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intermet.2015.03.013"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/app13127282"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010023\u201001517\u20100"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actamat.2017.09.062"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actamat.2024.120614"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scriptamat.2020.05.025"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/21663831.2016.1153004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijplas.2024.103963"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202410521"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijplas.2024.103882"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actamat.2022.118602"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2020.10.073"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msea.2022.143203"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4966659"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actamat.2022.117617"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msea.2020.139323"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/21663831.2021.2024615"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.08.059"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2015.07.209"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actamat.2019.04.018"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchar.2017.12.034"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msea.2017.10.062"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijplas.2024.104166"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actamat.2023.118855"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10853\u2010015\u20109553\u20104"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010024\u201000602\u20105"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cossms.2018.05.003"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2023.06.054"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adem.201801215"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intermet.2019.01.004"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.07.061"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/21663831.2019.1584592"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.03.023"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scriptamat.2019.11.059"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110959"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/21663831.2023.2197942"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2024.08.059"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7TB02412F"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.7.1954"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmrt.2024.03.200"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V122.21.1579.1579"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c11787"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008415\u20108"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41529\u2010024\u201000425\u20101"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202102035"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actamat.2018.12.012"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msea.2012.09.024"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2021.02.022"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010020\u20100750\u20104"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2024.04.020"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/21663831.2019.1616331"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1324069111"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0921\u20105093(01)01173\u2010X"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0001\u20106160(64)90226\u20103"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijplas.2024.104237"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abj8114"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adj3974"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijplas.2024.104079"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046003\u20106"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.12.032"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308875"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202505213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202505213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202505213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:56:31Z","timestamp":1775638591000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202505213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":71,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/adhm.202505213"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202505213","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]},"assertion":[{"value":"2025-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e05213"}}