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Herein, we developed a multifaceted nanoplatform (CuO@SiO\n                    <jats:sub>2<\/jats:sub>\n                    @NO@Au, CSNA NPs) consisting of a cupric oxide (CuO) core, a mesoporous silicon nanoshell loaded with nitric oxide (NO), and in situ grown ultrasmall Au nanoparticles (NPs) for improved diabetic wound treatment. The results showed that the prepared CSNA NPs exhibited remarkable dual\u2010enzyme mimic activity of glucose oxidase (GOx) and peroxidase (POD), effectively oxidizing glucose to generate gluconic acid, thereby reducing the glucose levels and reversing the acidic wound microenvironment. In addition, the fabricated nanoplatform generated abundant H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , which was converted into highly toxic hydroxyl radical (\n                    <jats:bold>\u00b7<\/jats:bold>\n                    OH), leading to efficient bacterial eradication that was subsequently. Under near\u2010infrared (NIR) light irradiation, the CSNA nanozyme also triggered the release of NO gas and aided in the removal of bacterial biofilms, collectively improving the wound microenvironment. By integrating chemodynamic therapy (CDT), photothermal therapy, and NO gas therapy, this self\u2010activatable NIR\u2010 augmented nanozyme provides a promising antimicrobial strategy for diabetic wound treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505240","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:42:23Z","timestamp":1769496143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An All\u2010in\u2010One Nanozyme for Synergistic Diabetic Wound Therapy: NIR\u2010Augmented NO Release and Microenvironment Modulation"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8744-850X","authenticated-orcid":false,"given":"Xueqin","family":"Wang","sequence":"first","affiliation":[{"name":"School of Bioengineering Henan University of Technology  Zhengzhou Henan P. R. 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