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Nevertheless, their clinical efficacy is often limited by insufficient antigen presentation and low immunogenicity. Here, a novel nanovaccine was developed that synergistically combines mitochondrial fission inhibition, tumor\u2010dendritic cell fusion, and metal\u2010phenolic nanoparticle technology. Tumor cells were pretreated with the mitochondrial fission inhibitor Mdivi\u20111, yielding antigen\u2011enriched cell membranes (CM(M)). Subsequently, these CM(M) were fused with the dendritic cell membranes (DCM) overexpressing B7 biomolecules to create a tumor\u2010dendritic cell fusion membrane (DCCM(M)). R848\u2010loaded metal\u2010phenolic nanoparticles (TF\/R848) were further coated with the fusion membrane to create a dual\u2010functional nanovaccine (TF\/R848@DCCM(M)). This nanovaccine increases immunogenicity and optimizes antigen presentation. The nanovaccine promotes dual T\u2010cell activation via direct antigen presentation and DC\u2010mediated cross\u2010presentation. TF\/R848@DCCM(M) showed remarkable anticancer activity in melanoma\u2010bearing mouse models, greatly reducing tumor development and extending longevity. Moreover, the nanovaccine enhanced the effects of immune checkpoint inhibitors, offering a promising strategy for combination immunotherapy. This study presents a novel, efficient platform for cancer immunotherapy, positioning a versatile and powerful approach for next\u2010generation tumor vaccines.<\/jats:p>","DOI":"10.1002\/adhm.202505255","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:21:56Z","timestamp":1768814516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antigen\u2010Enriched Tumor\u2010Dendritic Cell Fusion Membrane\u2010Coated Metal\u2010Phenolic Nanovaccine Enables Dual T\u2010Cell Activation for Robust Cancer Immunotherapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Lishang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics Xiangya School of Pharmaceutical Sciences Central South University  Changsha Hunan Province P. R. 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