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It is one of the leading causes of post\u2010surgical hospital readmission and is a major burden on global health systems. In light of the growing threat of antibiotic resistance, improving efficacy of traditional antimicrobials, such as the broad\u2011spectrum oxidizing biocide hydrogen peroxide, is of growing importance. In particular, solid peroxy\u2010compounds can offer prolonged action and sustained delivery of both oxygen and reactive oxygen species, offering both infection control and microenvironmental modulation. This review presents the current progress on antimicrobial dressings, comprehensively covering the application of solid peroxide\u2010releasing compounds in the treatment of infected wounds for antimicrobial control and acceleration of wound healing. Calcium peroxide (CaO\n                    <jats:sub>2<\/jats:sub>\n                    ) loaded biomaterials are found to be the most studied solid peroxide in the literature (90%; 30 studies), and the average improvement in healing of these reports was 26 \u00b1 14%. However, biomaterial formulations are often complex with multiple ingredients, and an analysis of 17 studies that included peroxide\u2010free but otherwise complete formulations identified that the improvements in wound healing attributable to peroxide loading itself were significant, P &lt; 0.05, in 8 of 17 studies. Additionally, infected wound healing, the potential biological roles of metal ions, strategies to control ROS\/O\n                    <jats:sub>2<\/jats:sub>\n                    release, and the translational outlook\/market readiness of peroxide materials are discussed.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505259","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T06:56:48Z","timestamp":1770015408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5310-4362","authenticated-orcid":false,"given":"Ayden","family":"Watt","sequence":"first","affiliation":[{"name":"Division of Surgical and Interventional Sciences Department of Surgery Faculty of Medicine and Health Sciences McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chably","family":"Rachella","sequence":"additional","affiliation":[{"name":"Division of Surgical and Interventional Sciences Department of Surgery Faculty of Medicine and Health Sciences McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Jaloux","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery McGill University Health Centre  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8548-6625","authenticated-orcid":false,"given":"Joshua","family":"Vorstenbosch","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery McGill University Health Centre  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Hart","sequence":"additional","affiliation":[{"name":"Jo Miller Orthopaedic Research Laboratory McGill University Hospital Centre  Montreal Canada"},{"name":"Division of Orthopaedic Surgery McGill University Health Centre  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8986-6326","authenticated-orcid":false,"given":"Michael","family":"Tanzer","sequence":"additional","affiliation":[{"name":"Jo Miller Orthopaedic Research Laboratory McGill University Hospital Centre  Montreal Canada"},{"name":"Division of Orthopaedic Surgery McGill University Health Centre  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine","family":"Merle","sequence":"additional","affiliation":[{"name":"Chemical Engineering Polytechnique Montr\u00e9al  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3543-6042","authenticated-orcid":false,"given":"Jake","family":"Barralet","sequence":"additional","affiliation":[{"name":"Division of Surgical and Interventional Sciences Department of Surgery Faculty of Medicine and Health Sciences McGill University  Montreal QC Canada"},{"name":"Faculty of Dental Medicine and Oral Health Sciences McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1731791"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00715-1"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/UPO9781922064004"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2017.0761"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671\u2010018\u20100234\u20109"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0608"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00067.2017"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000225431.63010.1b"},{"key":"e_1_2_14_10_1","volume-title":"StatPearls Treasure Island (FL)","author":"Wallace H. 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