{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:51:30Z","timestamp":1791442290495,"version":"4.3.3"},"reference-count":50,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Adhesions are common post\u2010surgical complications where fibrous tissue bridges adjacent surfaces following tissue injury. Although Seprafilm is a widely used clinical prophylactic, it often proves inadequate due to suboptimal mechanical stability and applicability. Solution Blow Spinning (SBS) enables the formation of polymer fibers tailored to complex geometries with excellent tissue adherence. Poly(D,L\u2010lactide\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010caprolactone) (PLCL) polymer has shown promise as an adhesions barrier but remains inconsistent because of its inherent tackiness and hydrophobicity. Here, high molecular weight (HMW) PLCL (40 or 80\u00a0kDa) was blended with low molecular weight (LMW) polyethylene glycol (PEG, 1 or 3\u00a0kDa). In vitro studies confirmed that PLCL\/PEG fibers achieved tissue adhesion strengths above 10\u00a0kPa and sustained mechanical performance throughout clinically relevant degradation timelines. Blending PEG changes the surface composition of the spray\u2010deposited mats, substantially improving the hydrophilic character and lowering protein adherence in vitro. In a murine cecal ligation model, the PLCL\/PEG blends demonstrated significantly reduced adhesion severity and incidence compared to both untreated and Seprafilm\u2010treated controls.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505289","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:39:21Z","timestamp":1773639561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sprayable Polymer Blends With Short\u2010Chain Surface Segregation for Preventing Postoperative Abdominal Adhesions"],"prefix":"10.1002","volume":"15","author":[{"suffix":"III","given":"Robert J.","family":"Morris","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejaswi","family":"Nori","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex I.","family":"Halpern","sequence":"additional","affiliation":[{"name":"Sheikh Zayed Institute For Pediatric Surgical Innovation Joseph E. Robert Jr. Center for Surgical Care Children's National Medical Center Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"LaPadula","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur V.","family":"Cresce","sequence":"additional","affiliation":[{"name":"U.S. Army DEVCOM Army Research Laboratory Battery Science Branch Energy Sciences Division  Adelphi Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Wright","sequence":"additional","affiliation":[{"name":"Sheikh Zayed Institute For Pediatric Surgical Innovation Joseph E. Robert Jr. Center for Surgical Care Children's National Medical Center Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D.","family":"Sandler","sequence":"additional","affiliation":[{"name":"Sheikh Zayed Institute For Pediatric Surgical Innovation Joseph E. Robert Jr. Center for Surgical Care Children's National Medical Center Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6657-3037","authenticated-orcid":false,"given":"Peter","family":"Kofinas","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering University of Maryland  College Park Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-1194-5_17"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2017.01.021"},{"key":"e_1_2_11_4_1","first-page":"60","article-title":"Intestinal Obstruction From Adhesions\u2013How Big is the Problem?","volume":"72","author":"Menzies D.","year":"1990","journal-title":"Annals of the Royal College of Surgeons of England"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314805"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10397\u2010007\u20100338\u2010x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(73)80123\u20100"},{"key":"e_1_2_11_8_1","first-page":"40","article-title":"Small Bowel Obstruction due to Postoperative Adhesions: Treatment Patterns and Associated Costs in 110 Hospital Admissions","volume":"83","author":"Menzies D.","year":"2001","journal-title":"Annals of the Royal College of Surgeons of England"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0276810"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314805"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590903230366"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42490-019-0005-0"},{"key":"e_1_2_11_13_1","first-page":"35","article-title":"Pathophysiology of Adhesion Formation and Strategies for Prevention","volume":"41","author":"Gomel V.","year":"1996","journal-title":"Journal of Reproductive Medicine"},{"key":"e_1_2_11_14_1","first-page":"293","article-title":"Pathophysiology of Adhesions","volume":"109","author":"Bu\u0163ureanu S.","year":"2014","journal-title":"Chirurgia"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102482\u201011\u201013"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000132988.50122.de"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)61687\u20106"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595\u2010021\u201002258\u2010w"},{"key":"e_1_2_11_19_1","first-page":"CD000475","article-title":"Barrier Agents for Preventing Adhesions After Surgery for Subfertility","volume":"2","author":"Farquhar C.","year":"2000","journal-title":"Cochrane Database of Systematic Reviews (Online)"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a019337"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304\u2010021\u201001117\u20100"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10397\u2010012\u20100741\u20109"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010021\u201002193\u2010x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039\u20106109(05)70574\u20100"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010019\u201000654\u2010x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c19662"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.3c00017"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202008395"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c01990"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111166"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10149"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201503691"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/mz500049x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.11.044"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.04.015"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10335"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/ACSAMI.3C00283\/ASSET\/IMAGES\/LARGE\/AM3C00283_0006.JPEG"},{"key":"e_1_2_11_38_1","first-page":"1","article-title":"Postoperative Adhesions: Current Research on Mechanisms, Therapeutics and Preventative Measures","volume":"2024","author":"Morris R. 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