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Here, we introduce an injectable, pH\u2010responsive amphiphilic hydrogel designed for quick hemostasis, strong wet\u2010tissue adhesion, and controlled therapeutic release. The hydrogel is prepared via a mild nucleophilic substitution reaction between tertiary amines of Poly(2\u2010(dimethylamino)ethyl methacrylate (PDMA) and gallic acidfunctionalized branched polyethyleneimine PEI(GA), using chloride\u2010terminated Pluronic F\u2010127 (Cl\u2010Plu\u2010Cl) as a crosslinker. The shear\u2010thinning, uniform prepolymer allows for consistent laparoscopic delivery and rapidly gels in situ (\u223c54 seconds) across a physiological pH range (5.07.4). In vitro and in vivo tests, including a mouse liver hemorrhage model, showed a 61% reduction in blood loss, comparable to Truseal (\u223c63%), while providing better injectability, biocompatibility, flexibility, and adjustable degradation and gelation properties. The (Cl\u2010Plu\u2010Cl\/PDMA\/PEI(GA)) hydrogel demonstrates strong adhesion strength (\u223c47 kPa) and withstands burst pressures up to 220 mmHg, exceeding typical arterial blood pressure. Sustained, pH\u2010responsive release of amoxicillin (\u223c60% at pH 7.4 and \u223c98% at pH 5.0 over 80 hours) displayed antibacterial activity against Staphylococcus aureus and MRSA. Alamar Blue and Live\/Dead assays confirmed over 90% cell viability, and the gradual in vitro degradation over three weeks indicates safe resorption and potential for clinical use.<\/jats:p>","DOI":"10.1002\/adhm.202505307","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:12:37Z","timestamp":1769839957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Injectable Stimuli\u2010Responsive Amphiphilic Hydrogel for Rapid Hemostasis, Robust Tissue Adhesion, and Controlled Drug Delivery in Trauma and Surgical Care"],"prefix":"10.1002","volume":"15","author":[{"given":"Arvind K. 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Engineering Indian Institute of Science  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2536-4508","authenticated-orcid":false,"given":"Maurice N.","family":"Collins","sequence":"additional","affiliation":[{"name":"School of Engineering Bernal Institute University of Limerick  Limerick 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