{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:30:33Z","timestamp":1792726233242,"version":"4.5.0"},"reference-count":52,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017577","name":"Basic Public Welfare Research Program of Zhejiang Province","doi-asserted-by":"publisher","award":["LTGY23H180008"],"award-info":[{"award-number":["LTGY23H180008"]}],"id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Immunogenic cell death (ICD) induced by calcium overload holds great promise for reversing the immunosuppressive tumor microenvironment (TME) and improving cancer immunotherapy. However, achieving sustained calcium dysregulation remains a major challenge. Herein, we report a novel nanoplatform, termed Ca@CMPN, which co\u2010delivers calcium hydride and curcumin using a mesoporous polydopamine carrier for synergistic ion\u2010interference and gas immunotherapy. Upon encountering the acidic TME, Ca@CMPN disintegrates to release Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , initiating intracellular calcium overload, and concurrently generates hydrogen gas (H\n                    <jats:sub>2<\/jats:sub>\n                    ). Crucially, the co\u2010released curcumin acts from within the cell, amplifying the calcium overload by disrupting organellar calcium homeostasis, thereby ensuring robust ICD. Meanwhile, H\n                    <jats:sub>2<\/jats:sub>\n                    serves as a potent immunoadjuvant to alleviate oxidative stress and remodel the immunosuppressive TME. Both in vitro and in vivo studies demonstrate that Ca@CMPN effectively inhibits tumor growth and reprograms the TME, as evidenced by enhanced dendritic cell maturation, activation of cytotoxic T cells, and elevated levels of pro\u2010inflammatory cytokines (interferon\u2010\u03b3 (IFN\u2010\u03b3) and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1)). This work presents a paradigm\u2010shifting strategy that synergizes ion\u2010interference therapy with hydrogen immunotherapy, offering a powerful nanoplatform to unlock the full potential of cancer immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505332","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T07:02:24Z","timestamp":1769324544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Synergistic Calcium Overload and Hydrogen Release Potentiate Robust Antitumor Immunity"],"prefix":"10.1002","volume":"15","author":[{"given":"Xueqi","family":"Liang","sequence":"first","affiliation":[{"name":"School of Food and Pharmacy Zhejiang Ocean University  Zhoushan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy Zhejiang Ocean University  Zhoushan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy Zhejiang Ocean University  Zhoushan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010kun","family":"Ouyang","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy Zhejiang Ocean University  Zhoushan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Ling","sequence":"additional","affiliation":[{"name":"School of Food and Pharmacy Zhejiang Ocean University  Zhoushan P. R. 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