{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:33:43Z","timestamp":1781645623324,"version":"3.54.5"},"reference-count":178,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI\u2010EX114\u201011319BI"],"award-info":[{"award-number":["NHRI\u2010EX114\u201011319BI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cancer drug development faces persistently low clinical success despite growing investment, mainly due to a translational gap driven by intratumoral heterogeneity, host\u2010tumor interactions, and resistance evolution. Tumor\u2010on\u2010chip platforms have emerged to bridge this gap by reconstructing human\u2010relevant microenvironments, yet current systems fall short in predictive power and scalability. Key limitations include: (i) incomplete tumor representation\u2010reliance on single\u2010line models, loss of stromal and immune diversity, and PDMS sorption\u2010induced dosing errors; (ii) workflow barriers\u2010non\u2010standardized fabrication, low throughput, endpoint\u2010biased analysis, and limited automation; and (iii) clinical integration issues\u2010restricted patient tissue access, lack of interoperable cryobank resources, and weak linkage to clinical outcomes. This review critically examines these challenges and proposes strategies such as modular biomimetic designs, immune\u2010stroma\u2010tumor co\u2010reconstitution using cryopreserved cells, standardized platforms with automated analytics, and cross\u2010validation with clinical or animal data to build regulatory confidence. We further discuss the impact of the FDA Modernization Act 2.0 and emerging market incentives driving non\u2010animal technologies. By coupling critique with pragmatic solutions, this review delineates a forward\u2010looking roadmap for advancing tumor\u2010on\u2010chip platforms into decision\u2010grade tools for precision oncology.<\/jats:p>","DOI":"10.1002\/adhm.202505347","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T06:44:21Z","timestamp":1770619461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tumor\u2010on\u2010Chip Platforms for Precision Oncology: Bridging Tumor Heterogeneity and Preclinical Drug Testing"],"prefix":"10.1002","volume":"15","author":[{"given":"Chiao\u2010Min","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering National Tsing Hua University  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8879-7098","authenticated-orcid":false,"given":"Hsuan\u2010Yu Steven","family":"Mu","sequence":"additional","affiliation":[{"name":"Fluidiconic Biotechnology Co. Ltd.  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-9396","authenticated-orcid":false,"given":"Ching\u2010Tso","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology National Taiwan University Hospital Hsin\u2010Chu Branch  Hsinchu Taiwan"},{"name":"Department of Oncology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Oncology National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3086-5094","authenticated-orcid":false,"given":"Jen\u2010Huang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering National Tsing Hua University  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00514-z"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01362-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-022-00001-9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_578_19"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.24977"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.02.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2786"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2015.12.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-214"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2012.14"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.08.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-11434-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-017-9687-6"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600-065X.2003.00081.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3LC00531C"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.4c00004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-004-0577-9"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14503"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2018.01.003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202100775"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.042"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12626"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.05.012"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.07.044"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2021.01.009"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215586"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344272"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00490"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0734-6"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306271"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.876291"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202303033"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-1031"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.655152"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5926"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13336"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.1.140"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.16884"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8LC00330K"},{"key":"e_1_2_10_41_1","unstructured":"G. H.Heppner W. R.Shapiro andJ. K.Rankin \u201cTumor Heterogeneity \u201d inPediatric Oncology 1: with a special section on Rare Primitive Neuroectodermal Tumors(1981) edited byG. B.Humphrey L. P.Dehner G. B.Grindey R. T.Acton Springer: Dordrecht."},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.05.028"},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","unstructured":"Y.Yuan \"Spatial heterogeneity in the tumor microenvironment \"Cold Spring Harbor perspectives in medicine6(2016):a026583.","DOI":"10.1101\/cshperspect.a026583"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06697-4"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2025.04.004"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-020-00849-5"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c15180"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105316108"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9001066"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1893"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2014.06.001"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.171"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01052"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw192"},{"key":"e_1_2_10_56_1","first-page":"24","article-title":"Immune Cell Infiltration Patterns and Survival in Head and Neck Squamous Cell Carcinoma","volume":"5","author":"Russell S.","year":"2013","journal-title":"Head & Neck Oncology"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03059"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-3696"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2006-0027"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052550"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-013-9420-1"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.6"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2640"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1030745"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20174155"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01655-5"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-0605"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.02.027"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-021-00874-2"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl15465"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2017.08.015"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.018"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240560108"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-020-02874-4"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2011.69"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.11.019"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804385"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3819"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.01.017"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21918"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20837"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11156"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2609"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3870"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.08.022"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5416923"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2087204"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01748-4"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2007.11.009"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-011-0066-6"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20170164"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-02102-4"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04575-9"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00004214"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0179-3"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02476-1"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.251"},{"key":"e_1_2_10_98_1","first-page":"1609","article-title":"A Perspective on Anti\u2010EGFR Therapies Targeting Triple\u2010negative Breast Cancer","volume":"6","author":"Nakai K.","year":"2016","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-020-01296-5"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0348"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70214-5"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1164535"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.92"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0095-3"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2015.0375"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-022-00174-y"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302268"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2012.10.004"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0727"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080889"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001513"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-021-01065-y"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1383456"},{"key":"e_1_2_10_114_1","doi-asserted-by":"crossref","unstructured":"S.AgtenandB.Wu \u201cInnovation in the Chinese Biopharma Sector: From Me\u2010too to First\u2010in\u2010Class \u201d inBiopharma in China(2024) Palgrave Macmillan Singapore.","DOI":"10.1007\/978-981-97-1471-1_4"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-112122-104310"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-025-02063-0"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18374"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-024-02980-6"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10404-021-02502-2"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-018-0023-x"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15080926"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-024-01191-5"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500427"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddtec.2017.03.002"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-0993-5"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2018.0215"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202401994"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101475"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49386-8"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13234258"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-022-00466-9"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1LC00348H"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c02142"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-024-00994-y"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0227135"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.151202"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42242-020-00112-5"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21914"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2989"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42171-z"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c01377"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63096-3"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31106"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.05.008"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202201436"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.09.043"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202207606"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000880"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202002444"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4LC00990H"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915745"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00797-2"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2111380"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801005"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.219"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56275-1"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2021.11.006"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0LC00799D"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-021-01630-4"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300692"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.571777"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1097\/00130404-200203000-00002"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbt.2025.03.004"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-024-00958-2"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448254"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1LC00241D"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5943"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adg6228"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2017.1317244"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2007.17"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2009.08.004"},{"key":"e_1_2_10_172_1","first-page":"1","article-title":"Role of in Vitro Two\u2010dimensional (2D) and Three\u2010dimensional (3D) Cell Culture Systems for ADME\u2010Tox Screening in Drug Discovery and Development: A Comprehensive Review","volume":"11","author":"Chunduri V.","year":"2023","journal-title":"ADMET and DMPK"},{"key":"e_1_2_10_173_1","doi-asserted-by":"crossref","unstructured":"J.Lansita A.McDougal J.Sohn andS. L.Weis \"Regulatory toxicology for biopharmaceuticals: preparing for pre\u2010IND interactions and avoiding IND pitfalls for oncology and non\u2010oncology products \" inTranslational Medicine(2021). First Ed. edited byJ. A.CavagnaroandM. E.Cosenza CRC Press.","DOI":"10.1201\/9781003124542-19"},{"key":"e_1_2_10_174_1","doi-asserted-by":"crossref","unstructured":"R.ChopraandF. I.Raynaud \u201cPreclinical Studies to Enable First in Human Clinical Trials \u201d inPhase I Oncology Drug Development(2020) edited byT. A.Yap J.Rodon andD. S.Hong Springer International Publishing Cham.","DOI":"10.1007\/978-3-030-47682-3_3"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-024-00476-9"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0402-9"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202412815"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2LC00611A"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2020.11.014"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202505347","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202505347","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202505347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:26:57Z","timestamp":1781501217000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202505347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,8]]},"references-count":178,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/adhm.202505347"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202505347","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,8]]},"assertion":[{"value":"2025-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e05347"}}