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Here, we demonstrated that high intensity of negative charge on fluorinated ethylene propylene electrets (ranging from \u22121252 \u00b1 66 V\/\u22120.465 \u00b1 0.025 mC\u2219m\n                    <jats:sup>\u22122<\/jats:sup>\n                    to \u22122838 \u00b1 95 V\/\u22121.055 \u00b1 0.035 mC\u2219m\n                    <jats:sup>\u22122<\/jats:sup>\n                    ) can direct self\u2010assembly of fibrinogen and guide platelet adhesion for surface enrichment. Detailed fibrinogen adsorption tests with a series of protein concentrations and incubation durations showed that the negative electrets induced fibrinogen networks quickly and were more porous compared to the positive ones. In addition, an extremely low binding energy of X\u2010ray photoelectron spectroscopy N1s (398.2 eV) and Fermi resonance associated Amide A and Amide B bands were exclusively detected on fibrinogen\u2010incubated negative electrets, indicating that the negative surface charge interacted with the fibrinogen via producing and accumulating orient water hydrated sodium ions, which coordinate with the \u03b3400\u2010401 histidine dipeptides in the \u03b3C of the absorbent fibrinogen D domains and facilitated the exposure of the \u03b3400\u2010411 sequences, mediating platelet adhesions on the electrets free of premature activation. Since fibrinogen is a naturally present protein in the human body, this proof\u2010of\u2010concept study provides new insights into advancing implantable biomaterials to orchestrate tissue integration at the protein and cellular levels.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505356","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:58:44Z","timestamp":1774270724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Negative Electrets Directed Fibrinogen Assembly for Surface Enrichment of Platelets"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-4252","authenticated-orcid":false,"given":"Zhong","family":"Wang","sequence":"first","affiliation":[{"name":"Interfacial Electrochemistry and Biomaterials School of Materials Science and Engineering East China University of Science &amp; Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Intelligent Sensing and Detection Technology School of Mechanical and Power Engineering East China University of Science &amp; Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6369-7488","authenticated-orcid":false,"given":"Hao","family":"Geng","sequence":"additional","affiliation":[{"name":"Advanced Carbon Materials Research Center School of Materials Science and Engineering Changzhou University  Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6315-2648","authenticated-orcid":false,"given":"Xunlin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Intelligent Sensing and Detection Technology School of Mechanical and Power Engineering East China University of Science &amp; Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Jiaotong University Affiliated Sixth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5209-4497","authenticated-orcid":false,"given":"Huiliang","family":"Cao","sequence":"additional","affiliation":[{"name":"Interfacial Electrochemistry and Biomaterials School of Materials Science and Engineering East China University of Science &amp; Technology  Shanghai China"},{"name":"Engineering Research Center for Biomedical Materials of the Ministry of Education East China University of Science &amp; Technology  Shanghai China"},{"name":"Key Laboratory for Ultrafine Materials of the Ministry of Education East China University of Science &amp; Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0110-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222-024-00269-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2013.02.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.0022-0337.2003.67.8.tb03681.x"},{"key":"e_1_2_10_6_1","first-page":"Zc26","article-title":"Effect of Platelet\u2010Rich\u2010Plasma (PRP) and Implant Surface Topography on Implant Stability and Bone","volume":"8","author":"Kundu R.","year":"2014","journal-title":"Journal of clinical and diagnostic research: JCDR"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30295"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1657698"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.10.008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36460"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.2c01057"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2010.12.007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.8.2967.bloodjournal8882967"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00303a028"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202508"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adem.200900084"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","unstructured":"A. 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