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However, the efficacy of ferroptosis induced by Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    is limited by several factors, including low Fe\n                    <jats:sup>2+<\/jats:sup>\n                    concentration, restricted Fenton\u2010active sites, excessive glutathione (GSH), and insufficient acidity of tumor cells. In this study, MoS\n                    <jats:sub>2<\/jats:sub>\n                    \u2010doped Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    , with peroxidase and glutathione oxidase\u2010like activities, was functionalized with tamoxifen (TAM) and coated with bovine serum albumin (BSA) to construct Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    \/MoS\n                    <jats:sub>2<\/jats:sub>\n                    @TAM\/BSA (FMTB) nanoparticles. The incorporation of MoS\n                    <jats:sub>2<\/jats:sub>\n                    facilitated the generation of abundant oxygen vacancies, which increased the number of active sites, acted as a co\u2010catalyst to accelerate the reduction of Fe\n                    <jats:sup>3+<\/jats:sup>\n                    to Fe\n                    <jats:sup>2+<\/jats:sup>\n                    , and promoted GSH consumption, resulting in a 51.3% increase in Fenton activity and a 4.3\u2010fold enhancement in GSH consumption compared to Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    alone. The released TAM inhibited mitochondrial complex I and improved tumor cellular acidity, thereby\u00a0creating a conducive environment for the Fenton reaction. By enhancing peroxidase\u2010like activity through co\u2010catalysis and reducing cellular pH, FMTB achieved a 70.6% tumor growth inhibition, in contrast to the 20.8% inhibition observed with Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    alone. Furthermore, the FMTB\u2010mediated tumor\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>2<\/jats:sub>\n                    \u2010weighted MRI signal was attenuated by 17% compared to that of Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    . Thus, this multienzyme\u2010based platform presents a novel strategy for highly efficient ferroptosis therapy against tumors by enhancing Fenton reaction efficiency and depleting GSH.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505441","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T05:38:23Z","timestamp":1770097103000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["MoS\n                    <sub>2<\/sub>\n                    \u2010Doped Iron Oxide Nanozyme with Co\u2010Catalytic Enhancement for Tumor Ferroptosis Guided by Magnetic Resonance Imaging"],"prefix":"10.1002","volume":"15","author":[{"given":"Xiaoxun","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging National Center for Magnetic Resonance in Wuhan Wuhan Institute of Physics and Mathematics Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences  Wuhan P. 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