{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:40:58Z","timestamp":1790480458308,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018951","name":"Institut Pierre-Gilles de Gennes","doi-asserted-by":"publisher","award":["ANR\u201010\u2010EQPX\u201034"],"award-info":[{"award-number":["ANR\u201010\u2010EQPX\u201034"]}],"id":[{"id":"10.13039\/501100018951","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["772487"],"award-info":[{"award-number":["772487"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The gut epithelium ensures nutrient absorption and barrier protection, functions tightly linked to its 3D architecture and dynamic mechanical activity. To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon\u2010on\u2010chip that integrates tunable topography, stiffness and peristalsis\u2010like motion within a physiologically relevant microenvironment. The model employs 3D scaffolds composed of either pure collagen I or mechanically reinforced interpenetrated network (IPN) made of collagen I and PEGDA. Tensile tests mimicking peristalsis revealed that both hydrogels soften upon stretching, with the IPN maintaining higher stiffness than pure collagen. Using this platform, we applied cyclic stretching for 24 to 72 h to co\u2010cultures of stromal and epithelial cells, and systematically assessed the contributions of stiffness, curvature and shear stress. We found that the stretching was a dominant factor governing epithelial behavior, markedly enhancing proliferation and apicobasal polarization without altering differentiation. Altogether, this work introduces a\u00a0next\u2010generation colon\u2010on\u2010chip\u00a0that unites mechanical control and biological complexity, providing a powerful tool to unravel how physical cues orchestrate intestinal homeostasis and paving the way for modeling disease states such as colorectal cancer and inflammation.<\/jats:p>","DOI":"10.1002\/adhm.202505483","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T07:01:03Z","timestamp":1769324463000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem"],"prefix":"10.1002","volume":"15","author":[{"given":"Moencopi","family":"Bernheim\u2010Dennery","sequence":"first","affiliation":[{"name":"UMR 168 CNRS\u2010Institut Curie IPGG PSL Research University  Paris France"},{"name":"UMR 144 CNRS\u2010Institut Curie PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauriane","family":"G\u00e9r\u00e9mie","sequence":"additional","affiliation":[{"name":"UMR 168 CNRS\u2010Institut Curie IPGG PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Brun","sequence":"additional","affiliation":[{"name":"UMR 7615 UPMC Sorbonne\u2010Universit\u00e9 CNRS ESPCI Paris PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Chassatte","sequence":"additional","affiliation":[{"name":"UMR 168 CNRS\u2010Institut Curie IPGG PSL Research University  Paris France"},{"name":"UMR 144 CNRS\u2010Institut Curie PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Gropplero","sequence":"additional","affiliation":[{"name":"UMR 168 CNRS\u2010Institut Curie IPGG PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9da","family":"Bouras","sequence":"additional","affiliation":[{"name":"UMR 144 CNRS\u2010Institut Curie PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Choo","sequence":"additional","affiliation":[{"name":"UMR 144 CNRS\u2010Institut Curie PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Cinquin","sequence":"additional","affiliation":[{"name":"UMR 168 CNRS\u2010Institut Curie IPGG PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Marcellan","sequence":"additional","affiliation":[{"name":"UMR 7615 UPMC Sorbonne\u2010Universit\u00e9 CNRS ESPCI Paris PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-703X","authenticated-orcid":false,"given":"Danijela Matic","family":"Vignjevic","sequence":"additional","affiliation":[{"name":"UMR 144 CNRS\u2010Institut Curie PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0027-352X","authenticated-orcid":false,"given":"St\u00e9phanie","family":"Descroix","sequence":"additional","affiliation":[{"name":"UMR 168 CNRS\u2010Institut Curie IPGG PSL Research University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.12.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.01.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001032"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-26938-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90648.2008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0LC00672F"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201021201\u20107"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.03.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2LC00696K"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10544\u2010017\u20100179\u2010y"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13708"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187880"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.25180"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp5001422"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1088\/1758\u20105090\/ab0478"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119404"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/app10196911"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102724\u20108"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522193112"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188302"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2lc40074j"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ib40126j"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3791\/50763"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.057778"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.10.051"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40883\u2010018\u20100074\u2010y"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.2c01980"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","unstructured":"A. X.Xin C.Gaydos andJ. J.Mao \u201cIn vitro Degradation Behavior of Photopolymerized PEG Hydrogels as Tissue Engineering Scaffold \u201d in2006 International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE2006) 2091\u20132093 https:\/\/doi.org\/10.1109\/IEMBS.2006.260811.","DOI":"10.1109\/IEMBS.2006.260811"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000435"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.1998.3966"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.2891373"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14098"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13619\u2010022\u201000137\u20104"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205061"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevResearch.4.023032"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201702033"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000076385"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.12.3717"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2015.1037417"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw9021"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360\u2010008\u20100264\u2010x"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119521"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.1449904"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2019"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200377"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adj7615"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202203377"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418857112"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119739"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20168"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adc9660"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.044"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20274"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0074317"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2012.08.005"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.08.001"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00518.2010"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605817200"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10316"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21407"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000041"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03\u201004\u20100235"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2022.12.007"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202505483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202505483","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202505483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:27:32Z","timestamp":1781501252000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202505483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,24]]},"references-count":63,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/adhm.202505483"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202505483","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,24]]},"assertion":[{"value":"2025-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e05483"}}