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In this study, we utilized a covalently closed circular RNA encoding bone morphogenetic protein\u20102 (BMP2 circRNA), which exhibits exceptional nuclease resistance and an extended half\u2010life, thereby enabling sustained and efficient BMP2 protein expression. The BMP2 circRNA was encapsulated into biomimetic nanovesicles (BNVs) derived from bone marrow mesenchymal stem cells (BMSCs) using co\u2010extrusion technology. These BNVs were then anchored onto the surface of micro\u2010arc oxidized titanium (Ti\u2010MAO) implants via polydopamine (PDA) adhesion, constructing a novel local gene delivery system. In vitro experiments confirmed that this system is not only efficiently internalized by cells but also evades lysosomal degradation, facilitating the sustained release of BMP2 protein. This, in turn, significantly promoted osteogenic gene expression and accelerated mineral deposition. Furthermore, in vivo animal studies demonstrated that the functionalized implant markedly enhanced bone regeneration, increasing both bone volume fraction and bone\u2010to\u2010implant contact. This study successfully integrated the inherent stability of circRNA with a biomimetic delivery strategy, offering an effective approach for improving implant osseointegration.<\/jats:p>","DOI":"10.1002\/adhm.202505504","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T08:35:36Z","timestamp":1775723736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Delivery of Engineered BMP2 circRNA via Biomimetic Nanovesicles Enhances Titanium Implant Osseointegration Through Translation\u2010Controlled Osteogenesis"],"prefix":"10.1002","volume":"15","author":[{"given":"Yichen","family":"Li","sequence":"first","affiliation":[{"name":"School of Stomatology Inner Mongolia Medical University  Hohhot China"},{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center For Oral Diseases &amp; Shaanxi Key Laboratory of Oral Diseases Department of Prosthodontics School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center For Oral Diseases &amp; Shaanxi Key Laboratory of Oral Diseases Department of Prosthodontics School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center For Oral Diseases &amp; Shaanxi Key Laboratory of Oral Diseases Department of Prosthodontics School of Stomatology The Fourth Military Medical University  Xi'an China"},{"name":"The Stomatology Department of Shanxi Provincial People Hospital Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center For Oral Diseases &amp; Shaanxi Key Laboratory of Oral Diseases Department of Prosthodontics School of Stomatology The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yong","sequence":"additional","affiliation":[{"name":"School of Stomatology Inner Mongolia Medical University  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[{"name":"School of Stomatology Inner Mongolia Medical University  Hohhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration National Clinical Research Center For Oral Diseases Shaanxi Key Laboratory of Stomatology. 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