{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:51:26Z","timestamp":1791442286922,"version":"4.3.3"},"reference-count":55,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20346 82402283"],"award-info":[{"award-number":["U22A20346 82402283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024MD763970"],"award-info":[{"award-number":["2024MD763970"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010009","name":"Heilongjiang Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBHZ23229"],"award-info":[{"award-number":["LBHZ23229"]}],"id":[{"id":"10.13039\/501100010009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010009","name":"Heilongjiang Provincial Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["LBHZ23237"],"award-info":[{"award-number":["LBHZ23237"]}],"id":[{"id":"10.13039\/501100010009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Rejection following heart transplantation remains a significant challenge in the medical science. In addition to the immune response, the inflammatory response and microvascular endothelial damage can exacerbate rejection; however, current therapies focus primarily on the immune response. Numerous studies have confirmed that miR\u2010126 regulates vascular inflammation and promotes angiogenesis. To achieve the precise targeted delivery of miR\u2010126, macrophage biomimetic ultrasound phase\u2010change cationic nanoparticles carrying miR\u2010126 (miR\u2010126\u2010MCNPs) are synthesized. Incorporation of the macrophage membrane enhances the anti\u2010phagocytic and inflammatory targeting of nanoparticles, thereby prolonging the circulation time and promoting aggregation in the transplanted heart. Using ultrasound\u2010targeted microbubble destruction (UTMD), the perfluoropentane nanoparticle core undergoes a phase change in the ultrasound irradiation zone, allowing the targeted delivery of macrophage membranes and miR\u2010126, and significantly improving the transfection efficiency of the miR\u2010126. Consequently, anti\u2010inflammatory effects are achieved, such as inhibition of macrophage and CD3\n                    <jats:sup>+<\/jats:sup>\n                    T cells infiltration, and alteration of M2\u2010type macrophage differentiation. In addition, this study demonstrates that the combination of miR\u2010126\u2010MCNPs with UTMD can alleviate the extent of vascular endothelial and interstitial fibrosis in transplanted hearts, increase angiogenesis, and improve microcirculation and cardiac function. This research provides a new strategy for the precision\u2010targeted therapy of cardiac transplant rejection.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505516","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:31:18Z","timestamp":1769754678000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasound\u2010Responsive Macrophage Biomimetic Phase\u2010Change Nanoparticles for Delivering miR\u2010126 Ameliorate Murine Heart Transplant Rejection"],"prefix":"10.1002","volume":"15","author":[{"given":"Haichao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ultrasound the First Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"},{"name":"Key Laboratories of Myocardial Ischemia Mechanism and Treatment Harbin Medical University Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haobo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"},{"name":"Key Laboratories of Myocardial Ischemia Mechanism and Treatment Harbin Medical University Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"},{"name":"Key Laboratories of Myocardial Ischemia Mechanism and Treatment Harbin Medical University Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"},{"name":"Key Laboratories of Myocardial Ischemia Mechanism and Treatment Harbin Medical University Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the First Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"},{"name":"Key Laboratories of Myocardial Ischemia Mechanism and Treatment Harbin Medical University Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"},{"name":"Key Laboratories of Myocardial Ischemia Mechanism and Treatment Harbin Medical University Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirui","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiecheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Diagnosis the Second Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"},{"name":"Key Laboratories of Myocardial Ischemia Mechanism and Treatment Harbin Medical University Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8883-8884","authenticated-orcid":false,"given":"Xiaoping","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound the Second Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Ultrasound molecular imaging Joint laboratory of Heilongjiang province (International Cooperation)  Harbin China"},{"name":"Key Laboratories of Myocardial Ischemia Mechanism and Treatment Harbin Medical University Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab416"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.062847"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.057400"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056158"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2401658121"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c04406"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20104642(21)00023\u20107"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202406758"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2010.03279.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01534"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.15.181"},{"key":"e_1_2_10_13_1","first-page":"6355","article-title":"Oral Administration of Encapsulated Bovine Lactoferrin Protein Nanocapsules Against Intracellular Parasite Toxoplasma Gondii","volume":"10","author":"Anand N.","year":"2015","journal-title":"International Journal of Nanomedicine"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.07.002"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.310557"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.135970"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016382"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010021\u201001423\u2010x"},{"key":"e_1_2_10_19_1","article-title":"Gene Therapy in Cardiovascular Disease: Recent Advances and Future Directions in Science: A Science Advisory From the American Heart Association","volume":"150","author":"Kim Y.","year":"2024","journal-title":"Circulation"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305300"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001780\u2010w"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-024-02171-w"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010023\u201000766\u20107"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211915"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211420"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202404608"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010023\u201000859\u20103"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573\u2010023\u201000002\u20102"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000631\u20102"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202402445"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900795"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010022\u201000699\u2010x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202107883"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305378"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1042730"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c04420"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14201616"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202303835"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201001859\u20104"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.45528"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.05.006"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010024\u201002376\u20107"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202411092"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.07.007"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065294"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab568"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119362"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37832-y"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57920"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310443"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2021.12.032"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202207271"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10197"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002597\u2010z"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032858"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310532"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202505516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202505516","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202505516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:15:34Z","timestamp":1791440134000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202505516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":55,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/adhm.202505516"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202505516","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]},"assertion":[{"value":"2025-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e05516"}}