{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:50:30Z","timestamp":1789325430977,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201025400034"],"award-info":[{"award-number":["RS\u20102025\u201025400034"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1A6A1A03023788"],"award-info":[{"award-number":["2018R1A6A1A03023788"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Kidney fibrosis, also known as renal fibrosis, is a condition wherein excessive scarring and interstitial inflammation of kidney tissues produce elevated levels of reactive oxygen species (ROS) and Human Pygopus 2 (\n                    <jats:italic>Pygo2<\/jats:italic>\n                    ) contributing to disease progression and severity. To prevent these conditions, a fibrotic kidney\u2010microenvironment\u2010responsive hydrogel (PD(diSe)\/shPygo2 Hydrogel) platform is designed and fabricated for providing therapy and protecting renal function. The therapeutic hydrogel provided the necessary ROS\u2010responsiveness via cleavage of the diselenide bonds in the presence of elevated oxidative stress promoting changes in the chemo\u2010physical property (adhesiveness, mechanical property, and electronic resistance) of the hydrogel. This transitioned the hydrogel into a more elastic state owing to a shift in Michael addition reaction between the surface amine groups in the PD(diSe) and the oxidized quinone moieties in the matrix facilitating the monitoring process. Moreover, in the presence of ROS\u2010induced 293T cells, the hydrogel exhibited differential electrical resistance and fluorescence compared with the 293T cells alone. Additionally, the presence of shPygo2 provides therapeutic protection to fibrotic scarring and renal function in unilateral ureteral obstruction (UUO) and adenine diet murine models by downregulating the\n                    <jats:italic>Pygo2<\/jats:italic>\n                    and\n                    <jats:italic>\u03b1\u2010SMA<\/jats:italic>\n                    secretion levels, along with promoting ROS scavenging through diselenide bond cleavage.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505517","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:19:16Z","timestamp":1768814356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oxidative Stress\u2010Responsive Chemo\u2010Physical Deformation of Hydrogel with Pygo2 Knockdown for Prevention of Kidney Fibrosis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4212-3757","authenticated-orcid":false,"given":"Hayeon","family":"Jo","sequence":"first","affiliation":[{"name":"Department of IT and Energy Convergence Korea National University of Transportation  Chungju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3040-6429","authenticated-orcid":false,"given":"Kaustuv","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of IT and Energy Convergence Korea National University of Transportation  Chungju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungho","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Materials Science Graduate School of JABA Wonkwang University  Iksan Jeonbuk State South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6874-3017","authenticated-orcid":false,"given":"Eun\u2010Jung","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Materials Science Graduate School of JABA Wonkwang University  Iksan Jeonbuk State South Korea"},{"name":"Integrated Omics Institute Wonkwang University  Iksan Jeonbuk State South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0358-6946","authenticated-orcid":false,"given":"Sung Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of IT and Energy Convergence Korea National University of Transportation  Chungju Republic of Korea"},{"name":"Department of Chemical and Biological Engineering Korea National University of Transportation  Chungju Republic of Korea"},{"name":"Department of Nanomedical Engineering Korea National University of Transportation  Chungju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107007\u20105\u201015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.093591"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2015.06.009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201039439\u20109"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043226\u2010x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001379\u20107"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201003417\u20105"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103724"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6665"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201904833"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202515330"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.11.010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010024\u201000889\u2010z"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011056"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13124"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021070942"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.5049\/EBP.2024.22.2.29"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0275392"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202414989"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201058059\u2010z"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00536"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202314500"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34902"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4592"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101843"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.10.016"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels6020014"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115395"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101342"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.11.019"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2024.06.027"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2022.12.025"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202007275"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404723"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.06.047"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12111931"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102369\u201014\u201056"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2050183"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9040141"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.23.156"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000034713"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2015.153"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010008\u20101048\u2010y"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf503207s"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB00757C"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2022.119699"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB01939F"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.12.009"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2016.12"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010023\u201002254\u2010x"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.05.034"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2020.06.028"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.116822"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.34172\/bi.2022.24256"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374\u2010019\u20100331\u20109"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.89105"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2023.09.008"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12580"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020400"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202505517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202505517","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202505517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:56:52Z","timestamp":1775638612000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202505517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":59,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/adhm.202505517"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202505517","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]},"assertion":[{"value":"2025-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e05517"}}