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A self\u2010healing resin composite incorporating glass ionomer cement\u2010based silica microcapsules (GIC\u2010SiO\n                    <jats:sub>2<\/jats:sub>\n                    MCs) was developed with controlled particle size covering macro\u2010 and micro\u2010fillers via optimized synthetic parameters. Microcracks ruptured MCs, releasing healing liquid that reacted with powder in the resin matrix to form crack\u2010sealing GIC. An optimal MCs ratio of 10wt% significantly improved hydrophilicity, flexural strength (from 58.6 to 87.8\u00a0MPa, reaching ISO standard), and cytocompatibility. A systematic methodology of self\u2010healing efficiency evaluation was established, integrating morphological and mechanical restoration. The 10 wt.% MC\u2010filled resin showed superior scratch closure in area and depth, recovery of fracture toughness (256.6%), and the highest comprehensive healing efficiency (161.2%). In a rat model, the 10 wt.% MC\u2010incorporated resin elicited mild inflammatory responses and significantly enhanced reparative dentin formation, previously unreported in resin\u2010based material. The developed self\u2010healing resin composite combined enhanced mechanical properties, autonomous self\u2010healing, anti\u2010caries activity, and bioactivity for remineralization and reparative dentin formation. This work offered a pioneering strategy and evaluative foundation for developing clinically applicable self\u2010healing dental materials, bridging the gap between experimental innovation and clinical practice.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505543","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:59:58Z","timestamp":1778140798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microencapsulated Glass Ionomer Cement\u2010Driven Dental Self\u2010Healing Resin Composites With Enhanced Mechanical Strength, Biocompatibility, and Reparative Dentin Formation"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8650-2614","authenticated-orcid":false,"given":"Yanyan","family":"Han","sequence":"first","affiliation":[{"name":"Department of General Dentistry Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. 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