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Although the arthroscopic repair can effectively suture the torn rotator cuff, the retear rate is still high, especially for patients with osteoporosis. Excessive oxidative stress, uncontrolled inflammatory infiltration Bone mass reduction, muscle atrophy, and fatty infiltration would gradually aggravate during the development of RCT, which would seriously hinder the effective repair of the repaired rotator cuff after arthroscopic surgery. Herein, a novel nanozyme\u2010based drug delivery system Nb\n                    <jats:sub>2<\/jats:sub>\n                    C@Mg\u2010MOF\/Pluronic F127 (NMP) consisting of niobium carbide (Nb\n                    <jats:sub>2<\/jats:sub>\n                    C), magnesium metal\u2013organic framework (Mg\u2010MOF), and a temperature\u2010sensitive hydrogel (Pluronic F127) was developed for effective regulation of inflammation and orderly regeneration of various tissues from bone to muscle. The in vitro and in vivo studies have shown that NM (Nb\n                    <jats:sub>2<\/jats:sub>\n                    C@Mg\u2010MOF) has excellent anti\u2010inflammatory properties. It could actively promote various tissue regeneration, including osteogenesis, inhibition of osteoclastogenesis, myogenesis, inhibit fatty infiltration and angiogenesis. This nanozyme\u2010based drug delivery system plays an effective role in promoting healing in the complex repair process of rotator cuff tears with osteoporosis, which would provide new insights and a promising strategy for treating of osteoporotic rotator cuff tears.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505546","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T04:57:09Z","timestamp":1770008229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mg\u2010Based Metal\u2013Organic Framework\u2010Modified MXene Nanozymes as a Comprehensive Therapeutic for Rotator Cuff Tear with Osteoporosis"],"prefix":"10.1002","volume":"15","author":[{"given":"Douhui","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi P. R. China"},{"name":"Department of Orthopedics Affiliated Hospital of Jiujiang University  Jiujiang Jiangxi P. R. China"},{"name":"Institute of Orthopedics of Jiangxi Province  Nanchang Jiangxi P. R. China"},{"name":"Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease  Nanchang Jiangxi P. R. China"},{"name":"Institute of Minimally Invasive Orthopedics Nanchang University  Nanchang Jiangxi P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi P. R. China"},{"name":"Institute of Orthopedics of Jiangxi Province  Nanchang Jiangxi P. R. China"},{"name":"Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease  Nanchang Jiangxi P. R. China"},{"name":"Institute of Minimally Invasive Orthopedics Nanchang University  Nanchang Jiangxi P. R. 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