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Here, we propose a multi\u2010printhead parallel printing strategy for the fabrication of barrier\/filler\u2010integrated GBR scaffolds for alveolar bone repair by upgrading a conventional melt extrusion\u2010based printing system with a parallelized 10\u2010printhead module. Compared with conventional\u00a0single\u2010printhead system, the parallel 10\u2010printhead configuration introduces thermal crosstalk, elevating local temperatures near the building platform and hindering the proper solidification of printed structures. By implementing cooling convection via fans and temperature compensation, we achieved simultaneous printing of 10 thin\u2010wall membrane structures with consistent geometry and interlayer\u2010bonding strength. Moreover, the system enables parallel printing of triply periodic minimal surface (TPMS) porous structures and barrier\/filler\u2010integrated GBR scaffolds, substantially enhancing overall manufacturing efficiency. In vivo studies using a rabbit alveolar defect model further demonstrated that the parallel\u2010printed integrated scaffolds effectively prevented soft tissue invasion while promoting robust bone regeneration, achieving outcomes superior to those of clinically established GBR strategies. The proposed multi\u2010printhead parallel printing technique offers a scalable, efficient way to mass\u2010produce clinically applicable polymeric implants.<\/jats:p>","DOI":"10.1002\/adhm.202505588","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:01:47Z","timestamp":1778216507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multi\u2010Printhead Parallel Printing of Polycaprolactone Barrier\/Filler\u2010Integrated Scaffolds for Alveolar Bone Repair"],"prefix":"10.1002","volume":"15","author":[{"given":"Zijie","family":"Meng","sequence":"first","affiliation":[{"name":"Frontier Institute of Science and Technology Xi'an Jiaotong University  Xi'an China"},{"name":"State Key Laboratory For Manufacturing Systems Engineering Xi'an Jiaotong University  Xi'an China"},{"name":"National Innovation Platform (Center) For Industry\u2010Education Integration of Medical Technology 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