{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:49:21Z","timestamp":1782402561093,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272821"],"award-info":[{"award-number":["82272821"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YG2025QNB30"],"award-info":[{"award-number":["YG2025QNB30"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Recent studies have revealed that the immunosuppression tumor mircroenvironment significantly impaired the efficacy of therapies against pancreatic cancer. Although photodynamic therapy (PDT)\u2010induced immunogenic cell death (ICD) offers a promising approach to stimulate the immune response, its effectiveness is considerably constrained by tumor hypoxia. In this work, we proposed an innovative nanozyme system based on dendritic mesoporous silica nanoparticles, co\u2010loaded with the photosensitizer IR808, MnO\n                    <jats:sub>2<\/jats:sub>\n                    , and Pt nanozymes, to amplify ICD through synergistic catalytic activities. Upon tumor accumulation, the released MnO\n                    <jats:sub>2<\/jats:sub>\n                    and Pt nanozymes simultaneously catalyze the decomposition of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    via their peroxidase\u2010 and catalase\u2010like activities, generating cytotoxic \u00b7OH while alleviating hypoxia to enhance IR808\u2010mediated PDT. Under 808\u00a0nm laser irradiation, the system demonstrates combined photothermal and augmented photodynamic effects, leading to potent tumor ablation and robust ICD induction. Comprehensive evaluations revealed that this nanozyme system not only exhibits remarkable tumor suppression through multimodal therapy but also effectively activates systemic antitumor immunity both in vitro and in vivo. Furthermore, the platform enables precise cancer diagnosis through dual\u2010modality magnetic resonance and near\u2010infrared imaging capabilities. This study presents a novel paradigm for enhancing ICD and establishes a versatile theranostic strategy for pancreatic cancer treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505709","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:52:08Z","timestamp":1777449128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Enhancement of Immunogenic Cell Death Through Photothermal\/Photodynamic Effects via Complex Nanoenzymes for Pancreatic Cancer Therapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Yinxun","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. 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