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This research presents a conformable, reusable, and stretchable hydrogel bioelectrode composed of inkjet\u2010printed PEDOT:PSS with a soft polyvinyl alcohol based substrate. This results in a strong, ion\u2010conductive matrix 100 \u00b1 16\u00a0kPa (n = 3) modulus, 660% \u00b1 72% (n = 3) stretchability) and stable impedance (&lt;6.4% drift over 72\u00a0h). The hydrogel bioelectrodes maintain &lt;15% resistance drift after 50 strain cycles. The hydrogel bioelectrodes can effectively capture six bioelectrical signals, including heart, brain, muscle, ocular, electrodermal, and sympathetic skin nerve activities with outstanding signal\u2010to\u2010noise (SNR) ratios (up to 70\u00a0dB). Brain's alpha activity (8\u201312\u00a0Hz) is clearly detected, confirming the hydrogel bioelectrode's sensitivity to low\u2010amplitude cortical signals. Sympathetic bursts in sympathetic skin nerve activity also show a 21% increase during the Valsalva maneuver, consistent with clinical observations. The hydrogel bioelectrodes also enable real\u2010time human\u2010computer interaction, where a subject\u2010calibrated algorithm converts oculography signals from both eyes into directional drone control commands.<\/jats:p>","DOI":"10.1002\/adhm.202505753","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:56:32Z","timestamp":1772996192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Skin Conformal Hydrogel Bioelectrodes for High\u2010Fidelity Electrophysiology and Human\u2013Machine Interfaces"],"prefix":"10.1002","volume":"15","author":[{"given":"Pritom","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Massachusetts Amherst  Amherst Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Crichton","sequence":"additional","affiliation":[{"name":"Paul M. 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