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Artificial sweeteners (AS) specifically acesulfame potassium, sodium saccharin, and sodium cyclamate, have recently demonstrated antimicrobial activity against multidrug\u2010resistant bacteria. In this study, polyvinyl alcohol (PVA)\u2010borate hydrogel is developed as a carrier for antimicrobial AS to combat wound infections. Through extensive optimization, we developed cytocompatible 8% AS\u2010loaded hydrogels with 3% PVA + 3% borax that\u00a0reduced the viability of multidrug\u2010resistant\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    AB5075 by 99.9% colony\u2010forming unit enumeration following 1 h hydrogel treatment. Most currently available wound dressings have limited efficacy against bacterial biofilms, but we demonstrate that each of these sweeteners can attenuate\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    and\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    dual\u2010microbial biofilms. Haemolysis and cell viability assays demonstrate excellent blood compatibility and non\u2010cytotoxic behavior of the sweetener\u2010loaded hydrogels. To further evaluate the clinical potential of these AS\u2010loaded hydrogels, we conducted a pilot Phase I clinical study with human volunteers focused on evaluating short\u2010term safety and irritancy. This study revealed that the dressings had no adverse effects on the volunteers. This research underscores the translational potential of hydrogels augmented with AS and their capacity to overcome many of the hurdles that typically lead to wound dressing failure.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505777","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:40:06Z","timestamp":1787809206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydrogels Augmented With Artificial Sweeteners can Inhibit Multidrug\u2010Resistant\n                    <i>Acinetobacter baumannii<\/i>\n                    Growth and Biofilm Formation While Demonstrating Safety in Pre\u2010Clinical Pilot Human Trials"],"prefix":"10.1002","author":[{"given":"Jie","family":"Han","sequence":"first","affiliation":[{"name":"Division of Biosciences Department of Life Sciences Antimicrobial Innovations Centre College of Health and Life Sciences Brunel University London  Uxbridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Soliman","sequence":"additional","affiliation":[{"name":"Division of Biosciences Department of Life Sciences Antimicrobial Innovations Centre College of Health and Life Sciences Brunel University London  Uxbridge UK"},{"name":"National Biofilms Innovation Centre School of Biological Sciences Faculty of Environmental and Life Sciences University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Mechanical and Aerospace Engineering Department Brunel University London  Uxbridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Krawiel","sequence":"additional","affiliation":[{"name":"Division of Biosciences Department of Life Sciences Antimicrobial Innovations Centre College of Health and Life Sciences Brunel University London  Uxbridge UK"},{"name":"National Biofilms Innovation Centre School of Biological Sciences Faculty of Environmental and Life Sciences University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-6352","authenticated-orcid":false,"given":"Ronan R.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Division of Biosciences Department of Life Sciences Antimicrobial Innovations Centre College of Health and Life Sciences Brunel University London  Uxbridge UK"},{"name":"National Biofilms Innovation Centre School of Biological Sciences Faculty of Environmental and Life Sciences University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01867\u20101"},{"key":"e_1_2_9_3_1","volume-title":"WHO Bacterial Priority Pathogens List 2024: Bacterial Pathogens of Public Health Importance, to Guide Research, Development, and Strategies to Prevent and Control Antimicrobial Resistance","year":"2024"},{"key":"e_1_2_9_4_1","first-page":"55","volume-title":"Advances in Microbiology, Infectious Diseases and Public Health. 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