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However, traditional clinical treatment methods are unable to effectively eliminate ROS. Herein, a dual ROS\u2010scavenging platform that integrates multifunctional niobium carbide (Nb\n                    <jats:sub>2<\/jats:sub>\n                    C) reinforced with curcumin (Cur) with UV\u2010crosslinked hydrogel microneedles (MN) is presented. In this system, Cur, acting as the primary scavenger, can rapidly neutralize extracellular ROS. Under near\u2010infrared (NIR) irradiation, the embedded Nb\n                    <jats:sub>2<\/jats:sub>\n                    C not only triggers the on\u2010demand release of curcumin but also, through its enzyme\u2010like peroxidase\u2010mimicking activity, acts as a secondary scavenger to eliminate deep intracellular ROS, thus providing a two\u2010stage antioxidant defense mechanism. This NIR\u2010enhanced dual\u2010action synergistic effect can balance the oxidative microenvironment, promote the repolarization of macrophages from the M1 type to the M2 type, facilitate angiogenesis, and produce a powerful photothermal combined antibacterial effect. The results of in vivo experiments indicate that the use of Nb\n                    <jats:sub>2<\/jats:sub>\n                    C\u2010CurCD\u2010GelMA MNs can significantly accelerate the healing of full\u2010thickness diabetic wounds. The mechanism lies in coordinating the reduction of inflammation and tissue regeneration. This study offers a sophisticated and safe treatment strategy for refractory diabetic wounds.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505787","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T09:22:22Z","timestamp":1770196942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nb\n                    <sub>2<\/sub>\n                    C\u2010Reinforced Hydrogel Microneedle as Dual ROS\u2010Scavenging Platform to Promote Diabetic Wound Healing"],"prefix":"10.1002","volume":"15","author":[{"given":"Zhi","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Tongren Hospital of Wuhan University (Wuhan Third Hospital)  Wuhan Hubei P. R. 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