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Here, we report a polymer nanoplatform that integrates near\u2010infrared II (NIR\u2010II) light\u2010triggered photothermal thrombolysis with intrinsic antithrombotic functionality. A novel semiconducting polymer, featuring intense NIR\u2010II absorption and exceptionally high photothermal conversion, is rationally engineered to enable rapid and localized light\u2010to\u2010heat thrombolysis. A thermosensitive hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) donor is also incorporated, generating multifunctional \u201cnanosweepers\u201d that combine synergistic photothermal and gas\u2010mediated thrombolytic activity. The formulation is further functionalized with bis\u2010serotonin groups, which confer myeloperoxidase\u2010 and hydrogen peroxide\u2010responsive thrombus\u2010targeting capability, ensuring selective accumulation and site\u2010specific therapy. This agent possesses robust NIR\u2010II absorption, high photothermal conversion efficiency (77.2%), and pronounced thrombus\u2010specific enrichment. Importantly, the combination of localized photothermal heating and on\u2010demand H\n                    <jats:sub>2<\/jats:sub>\n                    S release enable rapid, near\u2010complete thrombolysis in both carotid and lower\u2010limb arterial thrombosis models, achieving almost full restoration of blood flow. This work establishes a versatile and highly efficient strategy that integrates precise NIR\u2010II photothermal conversion with H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010mediated redox regulation, providing a promising platform for site\u2010specific multimodal synergistic treatment of life\u2010threatening thrombotic disorders. The findings offer new insights into the design of multifunctional, precision therapeutics for vascular disease management.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505802","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:22:43Z","timestamp":1771478563000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["NIR\u2010II Light\u2010Activated Nanoplatform for Synergistic Photothermal and H\n                    <sub>2<\/sub>\n                    S\u2010Mediated Thrombolysis"],"prefix":"10.1002","volume":"15","author":[{"given":"Lei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery of the First Affiliated Hospital and Institute for Cardiovascular Science Suzhou Medical College Soochow University  Suzhou 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Life Sciences, and Academy for Advanced Interdisciplinary Studies Nankai University  Tianjin China"},{"name":"Nankai International Advanced Research Institute (Shenzhen Futian)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3345"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-023-00532-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV22034"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201905145"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201701824"},{"key":"e_1_2_9_7_1","article-title":"Thrombolysis for Acute Deep Vein Thrombosis","volume":"10","author":"Watson L.","year":"2016","journal-title":"Cochrane Database of Systematic Reviews 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