{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:32:25Z","timestamp":1789525945604,"version":"build-2803163510"},"reference-count":79,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF\u20102026\u201065"],"award-info":[{"award-number":["ORF\u20102026\u201065"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Obstructive lacrimal duct disease has long been a clinical challenge due to the limitations of traditional silicone stents, which are functionally simple, non\u2010degradable, and prone to fibrosis\u2010induced restenosis. In this study, we present a breakthrough approach in the development of a multifunctional, drug\u2010loaded, biodegradable lacrimal duct stent based on electrospinning technology. By integrating mesoporous polydopamine nanoparticles loaded with dexamethasone (MPDA@DEX) into a PLCL\/Gel composite matrix, we successfully fabricated a biomimetic stent that exhibits desirable mechanical properties, hydrophilic surface characteristics, and controlled drug release capabilities. In vitro, the stent demonstrated excellent anti\u2010inflammatory and antioxidant activities, being associated with a shift of macrophages toward an M2\u2010like phenotype, significantly reducing intracellular ROS levels, and contributing to an inflammation\u2010repair balance via modulation of the MAPK\/Hippo\/FoxO signaling pathways. Transcriptomic sequencing further confirmed its ability to coordinate the regulation of the cellular transcription network, simultaneously suppressing pro\u2010inflammatory pathways while activating repair mechanisms. In vivo experiments further validated the stent's capacity to significantly reduce inflammation at the implantation site, inhibit collagen deposition, and promote angiogenesis. This research provides an innovative solution for lacrimal duct repair with active regulatory functions, representing a promising transition from \u201cpassive support\u201d to \u201cactive repair\u201d in therapeutic strategies.<\/jats:p>","DOI":"10.1002\/adhm.202505809","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T07:03:27Z","timestamp":1770620607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electrospun Lacrimal Stent for Synergistic Anti\u2010inflammatory and Antioxidant Therapy via Macrophage Polarization and Microenvironment Remodeling"],"prefix":"10.1002","volume":"15","author":[{"given":"Lu","family":"Han","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai P. R. China"},{"name":"Institute of Biomaterials and Biomedicine School of Food and Pharmacy Shanghai Zhongqiao Vocational and Technical University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Gong","sequence":"additional","affiliation":[{"name":"Tongren Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangliang","family":"Luo","sequence":"additional","affiliation":[{"name":"Tongren Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengchao","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shutao","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"EL\u2010Newehy","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Science King Saud University Riyadh 11451 P.O. Box 2455 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera Moydeen","family":"Abdulhameed","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Science King Saud University Riyadh 11451 P.O. Box 2455 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurbiya","family":"Abduriyim","sequence":"additional","affiliation":[{"name":"Bachu County Uyghur Medical Hospital  Kashi Xinjiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Lai","sequence":"additional","affiliation":[{"name":"Tongren Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9238-6171","authenticated-orcid":false,"given":"Xiumei","family":"Mo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials Shanghai Engineering Research Center of Nano\u2010Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University  Shanghai P. R. China"},{"name":"Institute of Biomaterials and Biomedicine School of Food and Pharmacy Shanghai Zhongqiao Vocational and Technical University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Qiu","sequence":"additional","affiliation":[{"name":"Tongren Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417\u2010013\u20102484\u20103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJO.IJO_1641_24"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001257"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/tjo.tjo_10_18"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S482069"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161\u20106420(99)00714\u20109"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201056491\u2010y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101259"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178679"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202304293"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.029"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay7608"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304641"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202300111"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.97335"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.102779"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","unstructured":"Z.Yang Y.Zhu J.Cheng et\u00a0al. \u201cPolyphenol\u2010Derived Nanoarmor\u2010Functionalized Photothermal Hydrogel Platform for Programmed Modulation of the Regenerative Microenvironment and Bone Defect Healing \u201dSmall(2025):10733 https:\/\/doi.org\/10.1002\/smll.202510733(Online First Publication).","DOI":"10.1002\/smll.202510733"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2012.0458"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S61375"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10020239"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13081270"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368916X693338"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010016\u20105763\u20109"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450124666230605150303"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400407a"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.02.003"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.1008360"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23916"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm300520u"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050541"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2020.04.029"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2016.09.004"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.06.121"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4BM01132E"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat1421"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142\u20109612(00)00101\u20100"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.01.039"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.12.1197"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.01.011"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3608"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010020\u201000477\u20109"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2019.11.004"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.02.004"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.11.004"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32651"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2018.06.041"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.2c00793"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41427\u2010019\u20100139\u20105"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11040182"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c15638"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13112661"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA02313J"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NJ01293A"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12989\u2010023\u201000548\u20104"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB02668J"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.24.021605.090737"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010016\u20100881\u20108"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010014\u20100550\u20108"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202316590"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856\u2010021\u201006490\u20101"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.02.005"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi12070770"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13091341"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01088"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma9080614"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c06661"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.04.003"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.11.5.9923"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1557\/s43580\u2010021\u201000091\u20104"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122942"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101895"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010020\u201003808\u20105"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23920"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.3109\/21691401.2016.1146731"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.04.048"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328206065125"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2008.02.010"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.teb.2013.0452"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2025.110741"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202505809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.202505809","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.202505809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:14:09Z","timestamp":1777029249000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.202505809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,8]]},"references-count":79,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/adhm.202505809"],"URL":"https:\/\/doi.org\/10.1002\/adhm.202505809","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,8]]},"assertion":[{"value":"2025-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e05809"}}