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Specifically, the amphiphilic structure of GL enabled encapsulation of triphenylphosphine\u2010glycyrrhetinic acid (TPP\u2010GA or TG) with a high loading capacity (&gt;\u00a024%); whereas its ortho\u2010hydroxy groups facilitated the anchoring of a polyethylenimine\u2010phenylboronic acid (PEI\u2010PBA) inner shell via borate ester bonds, followed by electrostatic coating of a hyaluronic acid outer shell. The TG@GPH micelles exhibited good physiological stability and efficient uptake by MDA\u2010MB\u2010231 cells; however, they dissociated under acidic and elevated ROS conditions due to acid\u2010labile cleavage of boronate ester bonds and ROS\u2010triggered oxidative breakage of carbon\u2010boron bonds, thereby rapidly releasing the TG payload. Thereafter, TG selectively targeted mitochondria and stimulated the opening of the mitochondrial permeability transition pores, resulting in mitochondrial impairment characterized by ROS overproduction, membrane potential depletion, and energy supply blockade, culminating in tumor cell apoptosis. Accordingly, TG@GPH suppressed tumor growth in MDA\u2010MB\u2010231 xenograft mouse models with an inhibition rate of 79.70%. Overall, the developed TG@GPH micelles displayed considerable potential for TNBC treatment and provided a compelling paradigm for transforming natural compounds into intelligent building blocks for sophisticated drug delivery systems.<\/jats:p>","DOI":"10.1002\/adhm.202505817","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T07:30:29Z","timestamp":1777015829000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Glycyrrhiza Glabra\u2010derived pH\/ROS Dual\u2010Responsive Phytomedicine Nanoplatform for Combatting Triple\u2010Negative Breast Cancer via Amplified Mitochondrial Damage"],"prefix":"10.1002","volume":"15","author":[{"given":"Fazhen","family":"Luo","sequence":"first","affiliation":[{"name":"Research Center for Health and Nutrition School of Public Health Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Institute of Chinese Materia Medica 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