{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:47:54Z","timestamp":1792615674644,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Critical\u2010sized maxillofacial bone defects are frequently exposed to pathological mechanical overload (MO), which disrupts cellular mechanosensing and compromises bone regeneration. However, strategies that protect osteogenic cells from overload\u2010induced mechanobiological dysfunction remain limited. Here, we develop a biomimetic scaffold incorporating liposomal quercetin (LQ) into a collagen\/silk fibroin\/nano\u2010hydroxyapatite matrix (LQ\u2010CSH) to restore osteoblast function under pathological loading conditions. MO induces cytoskeletal disorganization and oxidative stress, leading to inactivation of the mechanotransducer Yes\u2010associated protein (YAP). LQ treatment markedly reduces intracellular oxidative stress, preserves \u03b2\u2010actin cytoskeletal integrity, and restores YAP nuclear localization, thereby rescuing osteoblast proliferation and osteogenic differentiation. Pharmacological inhibition of \u03b2\u2010actin polymerization or YAP signaling abolishes these protective effects, confirming the critical role of the \u03b2\u2010actin\/YAP mechanosensing axis. In a rabbit mandibular critical\u2010sized defect model with simulated occlusal overload, LQ\u2010CSH scaffolds significantly enhance bone regeneration, improving bone volume fraction, mineral density, and trabecular architecture compared with control scaffolds. These findings highlight a mechanochemical strategy that protects osteogenic cells from overload\u2010induced dysfunction and provide a promising therapeutic approach for bone regeneration in mechanically hostile environments.<\/jats:p>","DOI":"10.1002\/adhm.202505818","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T07:38:13Z","timestamp":1777016293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Liposomal Quercetin\u2010Loaded Biomimetic Scaffolds Manage Mechanical Overload in Maxillofacial Regeneration by Stabilizing the \u03b2\u2010Actin\/YAP Mechanosensing Axis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2369-0142","authenticated-orcid":false,"given":"Rui","family":"Luo","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin 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Diseases Engineering Research Center of Trusted Behavior Intelligence Ministry of Education Tianjin Key Laboratory of Intelligent Robotics Institute of Robotics and Automatic Information Syste Nankai University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Tianjin's Clinical Research Center for Cancer  Tianjin China"},{"name":"Key Laboratory of Cancer Prevention and Therapy  Tianjin China"},{"name":"Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-0314","authenticated-orcid":false,"given":"Ruixin","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction  Tianjin 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