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Here, we report a hybrid scaffold that integrates a cancellous bone\u2013mimicking porous zinc framework with an interpenetrating poly(vinyl alcohol)\/TEMPO\u2010oxidized cellulose nanofiber (PVA\/TOCN) hydrogel. This design exploits hydroxyl\u2010 and carboxyl\u2010mediated chelation of Zn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    to regulate corrosion kinetics and stabilize ion release, while simultaneously reinforcing the hydrogel through secondary ionically crosslinked networks that provide extracellular matrix\u2010like bioactivity. In vitro, the hybrid scaffold maintained &gt;80% cell viability for 14 days, promoted osteogenic differentiation, and polarized macrophages toward a pro\u2010regenerative phenotype. In a rabbit bone defect model, it accelerated bone regeneration, reduced inflammation, and improved scaffold\u2013bone integration. By synchronizing degradation with tissue repair, this strategy establishes a class of immuno\u2010instructive, biodegradable implants with potential for orthopedic translation.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505864","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:32:51Z","timestamp":1774517571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ion\u2010Chelating Hydrogel Regulates Porous Zinc Scaffold Degradation for Osteoimmune Bone Repair"],"prefix":"10.1002","volume":"15","author":[{"given":"Junqin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering Southern University of Science and Technology  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Southern University of Science and Technology  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanxin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Southern University of Science and Technology  Shenzhen Guangdong China"},{"name":"Institute for Advancing Translational Medicine in Bone and Joint Diseases School of Chinese Medicine Hong Kong Baptist University  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Southern University of Science and Technology  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Southern University of Science and Technology  Shenzhen 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