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Conventional treatments, including surgery and paclitaxel\u2010based chemotherapy, are often limited by poor drug penetration into solid tumors, multidrug resistance, and the highly immunosuppressive tumor microenvironment. To overcome these challenges, we engineered a novel bacteria membrane\u2010fused biomimetic paclitaxel liposome (PLip@DMV) by incorporating bacteria membrane\u2010derived vesicles from attenuated\n                    <jats:italic>Salmonella<\/jats:italic>\n                    VNP20009. Administered via intraperitoneal injection, PLip@DMV not only delivered paclitaxel effectively but also leveraged the immunomodulatory properties of the\n                    <jats:italic>Salmonella<\/jats:italic>\n                    membrane. This led to significant antitumor immune activation within the metastatic tumor microenvironment, synergistically enhancing therapeutic efficacy and markedly prolonging the survival of tumor\u2010bearing mice. Furthermore, the enhanced delivery efficiency and sustained\u2010release characteristics of PLip@DMV resulted in significantly reduced systemic toxicity and tissue accumulation compared to free paclitaxel. Our findings demonstrate that PLip@DMV represents a more efficient, safer, and immunologically potentiated strategy for treating peritoneal metastatic ovarian cancer. This novel biomimetic nanocarrier holds significant promise for improving clinical outcomes in advanced OvCa.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505868","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:43:52Z","timestamp":1769755432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Salmonella<\/i>\n                    Bacteria Membrane\u2010Fusion Paclitaxel Loaded Liposomes for Enhanced Therapy of Intraperitoneal Metastatic Ovarian Cancer"],"prefix":"10.1002","volume":"15","author":[{"given":"Wei","family":"Duan","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"},{"name":"School of Pharmaceutical Sciences (Shenzhen) Sun Yat\u2010sen University  Guangzhou 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Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihong","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"},{"name":"School of Pharmaceutical Sciences (Shenzhen) Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinshuo","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen China"},{"name":"School of Pharmaceutical Sciences (Shenzhen) Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9759-2417","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Shenzhen 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