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To address these limitations, we introduce a novel bioengineered robotic system inspired by icebreakers, integrating multi\u2010functional nanomaterials for targeted, autonomous, and efficient\n                    <jats:italic>H. pylori<\/jats:italic>\n                    eradication. Our micro\u2010robots combine a platinum nanozyme\u2010based calcium carbonate complex with chitosan (Cs) modification, gastric epithelial cell membranes (CM) coating, and pronase (P) incorporation, enabling selective targeting and autonomous motility. Upon gastric acid exposure, this system undergoes controlled decomposition, generating carbon dioxide to propel movement, releasing pronase to penetrate and degrade mucus barriers, and deploying Pt nanozymes for deep bacterial eradication. This multi\u2010modal mechanism significantly enhances gastric retention, precision targeting, and therapeutic effectiveness. Our in vitro and in vivo studies validate its superior antibacterial activity, biocompatibility, and its unprecedented ability to mitigate\n                    <jats:italic>H. pylori<\/jats:italic>\n                    \u2010induced inflammation while preserving intestinal microbiota balance. By combining bioengineering, nanotechnology, and autonomous propulsion, this innovation represents a paradigm shift in\n                    <jats:italic>H. pylori<\/jats:italic>\n                    therapy, offering a precise, efficient, and resistance\u2010mitigating alternative to conventional treatments.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505900","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T07:31:10Z","timestamp":1766993470000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioengineered Microrobot for Targeted and Autonomous Eradication of\n                    <i>Helicobacter pylori<\/i>"],"prefix":"10.1002","volume":"15","author":[{"given":"Shali","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Xinqiao Hospital  NO.183 Chongqing 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