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Despite numerous biomaterial\u2010based strategies for adhesion prevention, their efficacy remains limited. To address this challenge, we synthesized\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    \u2010dimethylaminopropylamine\u2013conjugated hyaluronic acid (HA\u2010DMAPA), reporting the first preparation of this conjugate. This polyampholyte rapidly forms a hydrogel under physiological conditions via reversible electrostatic intra\u2010 and intermolecular interactions between the tertiary amines of DMAPA and the unreacted carboxyl groups of HA, exhibiting pH\u2010dependent gelation and degradation. The HA\u2010DMAPA hydrogel demonstrated mechanical stability near its isoelectric point (pH 5\u20135.5) and accelerated degradation at physiological pH 7.4, indicating its potential as an inflammation\u2010responsive polyampholyte. The material showed excellent injectability and instant self\u2010healing due to strong shear\u2010thinning properties, along with minimal cytotoxicity, reduced cell adhesion, enzymatic degradability, and remarkable hemocompatibility despite amine modification. In vivo, HA\u2010DMAPA effectively reduced severe postoperative peritoneal adhesions in both rat cecum abrasion and partial hepatectomy models. Overall, this newly developed polyampholyte hydrogel derived from functionalized hyaluronan is simple, safe, and highly practical for surgical use, offering a promising strategy for preventing severe adhesions that remain challenging to manage in clinical practice.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505907","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:23:03Z","timestamp":1776748983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Injectable Shear\u2010Thinning Polyampholyte Hydrogel Derived From Functionalized Hyaluronan for pH\u2010Responsive Prevention of Postoperative Peritoneal Adhesions"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3857-9317","authenticated-orcid":false,"given":"Yizhou","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Chemical System Engineering The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"},{"name":"Department of Bioengineering The University of Tokyo  Bunkyo\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-7734","authenticated-orcid":false,"given":"Arvind K. 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