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Despite extensive pharmacological investigations, effective and targeted therapies are still lacking. This study develops an innovative hyaluronic acid (HA)\u2010epigallocatechin gallate (EGCG)\u2010amino phenylboronic acid (PBA) based sub\u2010microgel (HAEP sub\u2010microgel) platform capable of integrating multiple dynamic interactions (esterification, boronic ester bonds, and hydrogen bonding) to achieve stability, lung delivery, and antioxidant activity. The HAEP sub\u2010microgel system is employed to deliver the anti\u2010inflammatory agent resatorvid (Res) to the injured lung in a bleomycin\u2010induced ALI mouse model. The HAEP@Res sub\u2010microgels (0.1\u20131.4\u00a0\u00b5m) exhibit excellent biocompatibility, effectively scavenge intracellular ROS in human lung fibroblasts in vitro. Moreover, the HAEP@Res intratracheal administration significantly reduces histopathological lung tissue injury, and suppresses pro\u2010inflammatory cytokine secretion (TNF\u2010\u03b1, IL\u20106, IL\u20101\u03b2) and gene expression (\n                    <jats:italic>Tlr4<\/jats:italic>\n                    ,\n                    <jats:italic>Tnf<\/jats:italic>\n                    ,\n                    <jats:italic>Il6<\/jats:italic>\n                    ,\n                    <jats:italic>Il1b<\/jats:italic>\n                    ,\n                    <jats:italic>Nrf2<\/jats:italic>\n                    ,\n                    <jats:italic>Nos2<\/jats:italic>\n                    ,\n                    <jats:italic>Tgfb<\/jats:italic>\n                    ,\n                    <jats:italic>Ccl2<\/jats:italic>\n                    ) in vivo. Altogether, this study establishes a versatile HAEP sub\u2010microgel\u2010based drug delivery system for anti\u2010inflammatory payloads, effectively alleviating lung inflammation and promoting ALI recovery, thereby demonstrating therapeutic potential for ALI\/ARDS and other inflammation\u2010related diseases.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505916","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:36:23Z","timestamp":1774341383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineering Resatorvid\u2010Loaded Sub\u2010Microgels of Epigallocatechin\u20103\u2010gallate\/Hyaluronic Acid to Treat Acute Lung Injury"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2455-2021","authenticated-orcid":false,"given":"Bo","family":"Liu","sequence":"first","affiliation":[{"name":"Mary &amp; Dick Holland Regenerative Medicine 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