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Here, we present a microfluidic wet\u2010spinning methodology for the biofabrication of cell\u2010laden alginate\u2010gelatin methacryloyl (GelMA) hydrogel\u2010based vessel\u2010like structures with controlled geometry and perfusable architecture. Using a sacrificial gelatin core within a core\u2013shell microfluidic device, tubular scaffolds were produced in a single continuous step under mild, cell\u2010compatible conditions. The alginate\u2010GelMA shell is fine\u2010tuned and loaded with human umbilical vein endothelial cells (HUVEC), yielding an endothelialized\u2010like, perfusable construct at the small\u2010vein scale (\u223c0.6\u20130.7\u00a0mm lumen diameter). As a proof\u2010of\u2010concept use case, the biofabricated vessel\u2010like structure was integrated into the breast cancer\u2010on\u2010a\u2010chip (BCoC) platform to showcase its feasibility in a 3D vascularized\u2010like tumor model for interrogating cancer cell propagation. Breast cancer spheroids were positioned in the surrounding GelMA matrix (perivascular\u2010like compartment), and THP\u20101 monocytes were circulated through the perfusion platform. Cancer cell dissemination, quantified as circulating tumor cells (CTCs), was modulated by the immune microenvironment: interleukin\u20104 (IL\u20104, anti\u2010inflammatory\u2010like) conditions promoted peak CTC release, whereas lipopolysaccharide (LPS, pro\u2010inflammatory\u2010like) stimulation suppressed this dissemination. Our model integrates the vascular, tumor, and immune compartments within a single construct, providing a versatile platform for investigations of breast cancer dissemination and tumor\u2010immune crosstalk.<\/jats:p>","DOI":"10.1002\/adhm.202505937","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:20:10Z","timestamp":1783491610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microfluidic Biofabrication of a Hydrogel Vessel\u2010Like Structure for Interrogating Tumor Cell Propagation in a Breast Cancer\u2010on\u2010a\u2010Chip Model"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4507-7146","authenticated-orcid":false,"given":"Alessia","family":"Paradiso","sequence":"first","affiliation":[{"name":"Faculty of Materials Science and Engineering Warsaw University of Technology  Warsaw 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