{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:07:23Z","timestamp":1783840043161,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"26","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52203013"],"award-info":[{"award-number":["52203013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["SCU2025J4183"],"award-info":[{"award-number":["SCU2025J4183"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Effective repair of vaginal defects, including those associated with Mayer\u2013Rokitansky\u2013K\u00fcster\u2013Hauser syndrome, requires biomaterials that combine tissue\u2010mimetic softness, hydration, mechanical resilience, and therapeutic activity. Here, we report a 3D\u2010printable multifunctional hydrogel scaffold enabled by tetrahydroxy diboron (THDB) chemistry for accelerated vaginal defect repair. THDB triggers rapid radical polymerization of 2\u2010hydroxyethyl methacrylate under oxygen\u2010rich conditions, forming a poly(2\u2010hydroxyethyl methacrylate) network strengthened by hydrogen bonding and B\u2500O coordination from multiple boron species. The incorporation of calcium ions (Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    ) and N,N\u2032\u2010methylenebisacrylamide further improves mechanical strength and water stability. The resulting hydrogel exhibits tensile strength above 1.0\u00a0MPa, compressive stress of \u223c2.0\u00a0MPa at \u223c70% strain, stable cyclic tensile and compressive performance, and long\u2010term aqueous stability with a swelling ratio of \u223c160% in phosphate\u2010buffered saline after 30 days. In addition, sustained release of THDB and Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    provides therapeutic bioactivity, including reactive oxygen species scavenging and activation of redox\u2010 and metabolism\u2010related signaling pathways. In a standardized rat model of full\u2010thickness vaginal defects, the hydrogel effectively promotes tissue repair, demonstrating its potential as a mechanically robust, swelling\u2010resistant, and bioactive scaffold for vaginal tissue reconstruction.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505939","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T03:54:41Z","timestamp":1780977281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tetrahydroxy Diboron\u2010Enabled 3D\u2010Printable Bioactive Hydrogel Scaffolds for Accelerated Repair of Vaginal Defects"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1758-5829","authenticated-orcid":false,"given":"Yi","family":"Wang","sequence":"first","affiliation":[{"name":"College of Chemistry and Materials Science Sichuan Normal University  Chengdu China"},{"name":"School of Mechanical and Aerospace Engineering Nanyang Technological University  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Sichuan Normal University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuedong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maling","family":"Gou","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second University Hospital Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2284-520X","authenticated-orcid":false,"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Mechanical and Aerospace Engineering Nanyang Technological University  Singapore 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