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Here we report a stage\u2010adaptive hydrogel dressing that integrates orthogonal, pathology\u2010stage\u2013driven activation with pathological\u2010factor neutralization coupled to triggered delivery. Two bioresponsive microspheres are embedded in the hydrogel: MMP\u20109\u2013responsive gelatin methacrylate (GelMA) microspheres loaded with a cationic antimicrobial peptide (ILRWPWWPWRRK\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    ), and ROS\u2010responsive HA\u2013PBA\u2013PVA microspheres loaded with vascular endothelial growth factor (VEGF). In the early stage, elevated MMP\u20109 cleaves GelMA microspheres, consuming MMP\u20109 and releasing AMP to eradicate MRSA and mitigate infection\u2010driven inflammation. In the later stage, ROS degrades HA\u2013PBA\u2013PVA microspheres, quenching ROS while releasing VEGF to restore endothelial function and neovascularization. In vitro, the system shows stimuli\u2010responsive release, potent antibacterial activity, ROS scavenging, and improved endothelial migration and tube formation under oxidative stress. In a streptozotocin\u2010induced diabetic rat model with MRSA\u2010infected full\u2010thickness wounds, the dual\u2010microsphere hydrogel accelerates closure, reduces bacterial burden and inflammation, enhances collagen deposition and mature vessel formation, and shows no systemic toxicity. This work demonstrates a translational, stage\u2010matched strategy for regulating infected diabetic wounds.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202505948","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:16:27Z","timestamp":1771665387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bioresponsive Dual Microspheres Embedded in a Hydrogel: A Sequentially Triggered Strategy for Regulating Diabetic Wound Healing"],"prefix":"10.1002","volume":"15","author":[{"given":"Kang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Chongqing Center for Clinical Laboratory Chongqing Academy of Medical Sciences Chongqing General Hospital School of Medicine Chongqing University  Chongqing China"},{"name":"Key Laboratory for Biorheological Science and Technology of Ministry of Education College of Bioengineering Chongqing 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