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Through reversible non\u2011covalent interactions, such as hydrogen bonding, hydrophobic effects, metal coordination, and electrostatic forces, GA molecules self\u2011assemble into dynamic three\u2011dimensional networks that exhibit tunable mechanical properties, self\u2011healing capability, and stimuli\u2011responsiveness. This review systematically elucidates the molecular mechanisms underlying GA\u2011based supramolecular hydrogel formation and highlights their broad biomedical applications. These include wound healing, cancer therapy, arthritis management, treatment of neurological disorders, and sustained drug delivery. Additionally, emerging roles in biosensing and monitoring technologies are discussed. We further address the challenges and future perspectives for the clinical translation of GA\u2010based hydrogels, emphasizing their potential as integrated therapeutic platforms that combine structural support with inherent bioactivity.<\/jats:p>","DOI":"10.1002\/adhm.202505953","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:49:38Z","timestamp":1773910178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Glycyrrhizic Acid\u2010Based Supramolecular Hydrogels as Multifunctional Platforms for Biomedical Applications"],"prefix":"10.1002","volume":"15","author":[{"given":"Liwen","family":"Xiao","sequence":"first","affiliation":[{"name":"Basic Medicine Research Innovation Center for Cardiometabolic Diseases Ministry of Education Southwest Medical University  Luzhou 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