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Herein, we report a gelatin sponge patch by one\u2010sided coating with N\u2010hydroxysuccinimide (NHS) ester\u2010functionalized poly (acrylic acid\u2010co\u2010N\u2010succinimidyl acrylate) (PANS), which acts by formation of covalent and hydrogen bonding cross\u2010links between polymer, blood proteins, gelatin, and tissue to seal the wound site and prevent hemorrhage during surgery. PANS exhibits robust lap\u2010shear strength of up to\u00a0114.4 \u00b1 8.7\u00a0kPa, enabling the PANS\u2010GS composite to achieve effective wet\u2010tissue adhesion, while macroporosity is preserved for rapid blood absorption. This dual\u2010function design allows simultaneous physical sealing and platelet enrichment with reduced dependence on fibrin\u2010mediated coagulation pathways. In rat hepatic laceration and femoral artery injury models, the composite sponge demonstrates superior hemostatic efficacy, with significant reductions in bleeding time and blood loss compared to clinically used sponges in both non\u2010heparinized and systemically heparinized subjects. Critically, biocompatibility assessments reveal minimal cytotoxicity and hemolysis, while histopathological analysis indicates no significant increase in inflammatory response compared with commercial gelatin sponge. These results establish a coagulation\u2010independent hemostatic strategy that integrates strong wet adhesion with preserved porosity, offering promise for managing anticoagulant\u2010associated bleeding, visceral trauma, and complex battlefield injuries.<\/jats:p>","DOI":"10.1002\/adhm.202505956","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T08:46:07Z","timestamp":1775292367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hemostatic Sponge With Excellent Wet Tissue Adhesion Performance for Anticoagulant\u2010Associated and Unsuturable Visceral Hemorrhage Management"],"prefix":"10.1002","volume":"15","author":[{"given":"Yuwei","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Medical Materials and Devices Institute of Biomedical Engineering Tianjin Institutes of Health Science Chinese Academy of Medical Sciences &amp; Peking Union 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