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This study developed a nanoparticle, Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @ZIF\u20108, endowed with superoxide dismutase (SOD)\u2010 and catalase (CAT)\u2010like enzyme\u2010mimetic activities. The nanocomposite not only synergistically neutralizes key ROS but also significantly alleviates oxidative stress and inflammatory responses in chondrocytes by modulating SIRT1\/Nrf2 axis. More importantly, the introduction of an external magnetic field (MF) was demonstrated to markedly enhance cellular uptake and retention of the nanoparticles, thereby providing superior cartilage protection and tissue repair compared to non\u2010targeted intervention. Macroscopic and histological evaluations confirmed that the cartilage morphology and matrix composition in the Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @ZIF\u20108 + MF group closely resembled those of healthy tissue, accompanied by notable downregulation of pro\u2010inflammatory cytokines (IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1) and catabolic enzymes (MMP\u20103, MMP\u201013). These findings highlight the potential of magnetically guided nanozyme therapy as a novel and efficacious approach for OA treatment, offering a multimodal solution to modulate the disease microenvironment and enhance regenerative outcomes.\n                  <\/jats:p>","DOI":"10.1002\/adhm.202600006","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T09:41:27Z","timestamp":1779442887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetic Field\u2010Actuated ZIF\u20108\u2010Encapsulated Fe\n                    <sub>3<\/sub>\n                    O\n                    <sub>4<\/sub>\n                    Nanoparticles Attenuate Osteoarthritis via Antioxidant Effects"],"prefix":"10.1002","volume":"15","author":[{"given":"Zongru","family":"Li","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Regenerative Medicine, Guangxi Engineering Center in Biomedical Materials For Tissue and Organ Regeneration, International Joint Laboratory On Regeneration of Bone and Soft Tissues, Collaborative Innovation Center of Regenerative Medicine and Medical Bioresource Development and Application Co\u2010Constructed By the Province and Ministry The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi P. 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