{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:49:13Z","timestamp":1782510553196,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In vitro arterial models offer ethical and robust alternatives for vascular research but require cytocompatible materials that replicate physiological mechanics. Poly(vinyl alcohol) (PVA) hydrogels produced by directional freezing and salting\u2010out (PVA DFSO) are anisotropic yet lack stability for cell culture. Herein, methacrylated PVA (PVA\u2010MA) hydrogels were fabricated by integrating directional freezing, salting\u2010out, and ultraviolet (UV)\u2010mediated covalent crosslinking to enhance mechanical performance and physicochemical stability. Two fabrication routes were examined: UV polymerization before (UVBSO) or after (UVASO) salting\u2010out. Tensile properties and anisotropy were quantified relative to the freezing direction, and stability was assessed by swelling and mass\u2010loss measurements. UVBSO hydrogels achieved the highest anisotropy (ratio \u2248 3.48), with Young's modulus of 50.8 kPa parallel (E||) and 14.1 kPa perpendicular (E\u22a5) to freezing direction but reduced stiffness (2.9\u2010fold lower E\u2225 than DFSO). In contrast, UVASO constructs demonstrated robust, arterial\u2010range performance (tensile strength \u2248 760\u00a0kPa; E\u2225 \u2248 378.6\u00a0kPa; \u223c2.5\u2010fold vs DFSO; ratio \u2248 3.26), reduced swelling without increasing mass loss, and sterilization compatibility. PVA\u2010MA hydrogels could be molded into artery\u2010like geometries and supported viable cell adhesion. This work presents a sterilizable, cytocompatible hydrogel with tunable anisotropy and arterial\u2010mimetic mechanics, advancing the development of vascular\u2010relevant in vitro artery models.<\/jats:p>","DOI":"10.1002\/adhm.202600010","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:06:53Z","timestamp":1778216813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physicochemical Reinforcement Unlocks Sterilization\u2010Stable Anisotropic Hydrogels for Cell\u2010Compatible Mock Arteries"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3019-4381","authenticated-orcid":false,"given":"Javiera","family":"Sanhueza Ortega","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering University of New South Wales  Sydney Australia"},{"name":"School of Mechanical and Manufacturing Engineering University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirthen","family":"Shanmuganathan","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering University of New South Wales  Sydney Australia"},{"name":"School of Mechanical and Manufacturing Engineering University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Poole\u2010Warren","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susann","family":"Beier","sequence":"additional","affiliation":[{"name":"School of Mechanical and Manufacturing Engineering University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulises","family":"Aregueta Robles","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.06.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.320263"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.05.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","unstructured":"C.Shen M.Zhang H.Keramati et\u00a0al. \u201cThe Anatomy of Coronary Risk: How Artery Geometry Shapes Coronary Artery Disease Through Blood Flow Haemodynamics \u2013 Latest Methods Insights and Clinical Implications \u201dpreprint arXiv(July 23 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