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However, effective intradiscal diffusion and timely in situ gelation remain challenging within the confined high\u2010pressure nucleus pulposus. Inspired by the temporal regulation of blood coagulation, we developed a biomimetic dual\u2010network hydrogel (named HAD\u2010HPTC) that achieves time\u2010programmed diffusion and delayed solidification to enhance delivery and retention. Upon injection, an initial physical network, formed through dynamic hydrogen bonding and coordination between hyaluronic acid\u2010phenylboronic acid (HA\u2010PBA) and tannic acid\u2010cerium metal polyphenol networks (TA\u2010Ce MPNs), enables fluid\u2010like diffusion and conformal defect filling, analogous to initial blood infiltration in wounds. Subsequently, a second chemical network gradually forms via thiol\u2010Michael addition between hyaluronic acid acrylate (HA\u2010AA) and dithiothreitol (DTT) under physiological conditions, achieving stable in situ gelation reminiscent of fibrin formation. This temporally programmed structure provides delayed gelation and improved diffusion, while integrated TA\u2010Ce MPNs confer antioxidant, anti\u2010inflammatory, and anti\u2010senescence functions. Furthermore, in vivo studies in rat and rabbit models demonstrated superior disc height preservation, extracellular matrix restoration, and inflammation suppression compared to conventional preformed hydrogels. These findings establish blood\u2010coagulation\u2010inspired, time\u2010programmed hydrogels as a promising platform for minimally invasive intervertebral disc regeneration.<\/jats:p>","DOI":"10.1002\/adhm.202600027","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:03:13Z","timestamp":1785301393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood\u2010Coagulation\u2010Inspired Dual\u2010Network Hydrogel with Delayed In Situ Gelation for Enhancing Intradiscal Diffusion and Promoting Intervertebral Disc Degeneration Repair"],"prefix":"10.1002","volume":"15","author":[{"given":"Minglang","family":"Zou","sequence":"first","affiliation":[{"name":"College of Biological Science and Engineering Fuzhou University  Fuzhou Fujian 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