{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:54:37Z","timestamp":1781855677302,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20591"],"award-info":[{"award-number":["U23A20591"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dentin hypersensitivity (DH) stems from exposed dentinal tubules, where external stimuli induce fluid movement, stimulate pulp nerves, and cause acute pain. A significant challenge in current DH management is that most commercially available desensitizing agents often lack both immediate and long\u2010term efficacy. To address this, a black phosphorus (BP) nanosheet\u2010composited methoxy poly(ethylene glycol)2k\u2010\n                    <jats:italic>block<\/jats:italic>\n                    \u2010poly(L\u2010methionine)\n                    <jats:sub>27<\/jats:sub>\n                    \u2010\n                    <jats:italic>block<\/jats:italic>\n                    \u2010poly(L\u2010lysine)\n                    <jats:sub>5<\/jats:sub>\n                    (PMK\n                    <jats:sub>5<\/jats:sub>\n                    ) cationic hydrogel (PMK\n                    <jats:sub>5<\/jats:sub>\n                    \/BP) operates through three steps to relieve DH, including ion flow blocking, the photo\u2010thermal effect of BP, and sustained release phosphate ions to enhance biomineralization, thereby achieving immediate efficacy and the potential for long\u2010term efficacy in DH treatment. The application of PMK\n                    <jats:sub>5<\/jats:sub>\n                    alone significantly reduces electrical conductivity from 0.21 to 0.08\u00a0mS, demonstrating immediate efficacy. With BP and 7\u00a0min of irradiation, the diameter of human dentinal tubules in the PMK\n                    <jats:sub>5<\/jats:sub>\n                    \/BP group decreases to a range of 0\u22121.70\u00a0\u00b5m, which is smaller than that in the DH\u2010model group. Furthermore, after treated human dentin slices are immersed in saliva for seven days, the dentinal tubule occlusion rate remains high at 91.82%, matching the immediate rate of 96.33%, indicating excellent one\u2010week stability. PMK\n                    <jats:sub>5<\/jats:sub>\n                    \/BP also exhibits higher levels of calcium (Ca) and phosphorus (P). These results demonstrate that PMK\n                    <jats:sub>5<\/jats:sub>\n                    \/BP provides an efficient clinical approach to DH treatment.\n                  <\/jats:p>","DOI":"10.1002\/adhm.71067","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:24:21Z","timestamp":1774851861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cationic Poly(amino acid)\/Black Phosphorus Hydrogel for Immediate and Durable Relief of Dentin Hypersensitivity Through Ion Flow Blockade, Photo\u2010Thermal Occlusion, and Biomineralization"],"prefix":"10.1002","volume":"15","author":[{"given":"Xinru","family":"Li","sequence":"first","affiliation":[{"name":"Department of Stomatology The First Hospital of Jilin University  Changchun P. R. 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