{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:49:46Z","timestamp":1792856986158,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271372"],"award-info":[{"award-number":["32271372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473303"],"award-info":[{"award-number":["52473303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25A20261"],"award-info":[{"award-number":["U25A20261"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51973090"],"award-info":[{"award-number":["51973090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515220045"],"award-info":[{"award-number":["2022A1515220045"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012734"],"award-info":[{"award-number":["2023A1515012734"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Healthcare Materials"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Myocardial ischaemia\/reperfusion injury presents significant clinical challenges driven by a self\u2010perpetuating cycle of oxidative stress and inflammation. Current therapeutic strategies fail to simultaneously address these interconnected pathological events. Here, we present T&amp;A\u2010Gel, a supramolecular peptide amphiphile hydrogel integrating \u03b1\u2010tocopherol and Angiotensin\u2010(1\u20107) (Ang\u2010(1\u20107)) through covalent conjugation to enable localized co\u2010delivery and synergistically disrupt this oxidative\u2010inflammatory feed\u2010forward circuit. Upon hierarchical self\u2010assembly into filamentous nanofibres, T&amp;A\u2010Gel forms a sustained\u2010release depot that exposes Ang\u2010(1\u20107) moieties while sequestering hydrophobic \u03b1\u2010tocopherol. This design enables \u03b1\u2010tocopherol to scavenge excess reactive oxygen species, ameliorating oxidative mitochondrial dysfunction and reducing cardiomyocyte apoptosis, while exposed Ang\u2010(1\u20107) acts as a selective Mas receptor (MasR) agonist, activating the protective MasR\/PI3K\/Akt signaling axis. This dual\u2010action mechanism suppresses NF\u2010\u03baB nuclear translocation and inhibits pro\u2010inflammatory cytokine cascades. In vitro, T&amp;A\u2010Gel significantly enhanced hypoxia\/reoxygenation\u2010injured cardiomyocyte viability. In vivo, T&amp;A\u2010Gel demonstrated prolonged retention with substantial reduction in infarct size and cardiac necrosis biomarkers. Quantitative analysis confirmed substantial attenuation of interstitial fibrosis and cardiomyocyte hypertrophy, translating into restored ejection fraction and reduced ventricular dilation with excellent biocompatibility. These findings establish injectable supramolecular hydrogels as a powerful strategy for disrupting the interconnected injury cascade via mechanistically complementary payloads, offering a paradigm for precision cardioprotection.<\/jats:p>","DOI":"10.1002\/adhm.71082","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T09:15:24Z","timestamp":1774862124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bifunctional Peptide Amphiphile Hydrogel Orchestrates Concerted Antioxidant and Anti\u2010Inflammatory Actions to Counter Myocardial Ischemia\/Reperfusion Injury"],"prefix":"10.1002","volume":"15","author":[{"given":"Yuanyuan","family":"Wu","sequence":"first","affiliation":[{"name":"Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease Department of Cardiology and Laboratory of Heart Center Zhujiang Hospital Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siman","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Liao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease Department of Cardiology and Laboratory of Heart Center Zhujiang Hospital Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiming","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease Department of Cardiology and Laboratory of Heart Center Zhujiang Hospital Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease Department of Cardiology and Laboratory of Heart Center Zhujiang Hospital Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiye","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease Department of Cardiology and Laboratory of Heart Center Zhujiang Hospital Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information Technology Sun Yat\u2010sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2967-6920","authenticated-orcid":false,"given":"Zhimou","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Southern Medical University  Guangzhou P. R. China"},{"name":"Nankai International Advanced Research Institute Nankai University (Shenzhen Futian) Shenzhen Guangdong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7190-5307","authenticated-orcid":false,"given":"Jie","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Guangdong Provincial Key Laboratory of Precision Medical Diagnostics Nanfang Hospital Southern Medical University  Guangzhou P. R. China"},{"name":"Guangdong Engineering and Technology Research Center for Rapid Diagnostic Biosensors Guangdong Provincial Key Laboratory of Single\u2010cell and Extracellular Vesicles Nanfang Hospital Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2139-4750","authenticated-orcid":false,"given":"Yanbin","family":"Cai","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease Department of Cardiology and Laboratory of Heart Center Zhujiang Hospital Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00884-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30677-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c14445"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02253-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-024-01429-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202404319"},{"issue":"2","key":"e_1_2_9_8_1","first-page":"246","article-title":"Mitochondria Regulate Intracellular Coenzyme Q Transport and Ferroptotic Resistance via STARD7","volume":"25","author":"Deshwal S.","year":"2023","journal-title":"Nature Cell Biology"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40081-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c00509"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101292"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305363"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01688-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.307708"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.53644"},{"key":"e_1_2_9_16_1","first-page":"1365","article-title":"Cardioprotective Angiotensin\u2010(1\u20107) Peptide Acts as a Natural\u2010Biased Ligand at the Angiotensin II Type 1 Receptor","volume":"68","author":"Galandrin S.","year":"2016","journal-title":"Cell Reports"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.703"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.124.22693"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad347"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101612"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c07161"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-0966-3"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2025.124149"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12012"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711837115"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja503882s"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00297"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.53644"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01390-0"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c05759"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202503324"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202307390"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adv8999"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c02030"},{"key":"e_1_2_9_35_1","article-title":"Peptide Hydrogel\u2010Drug Conjugates for Tailored Disease Treatment","volume":"23","author":"Cauwenbergh T.","year":"2024","journal-title":"Materials Today Bio"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-025-01981-6"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c02462"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122453"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121849"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20220005"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301615"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00820-3"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36629-3"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.06.039"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20230018"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.12.042"}],"container-title":["Advanced Healthcare Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71082","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adhm.71082","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adhm.71082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:43:06Z","timestamp":1781854986000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adhm.71082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":45,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/adhm.71082"],"URL":"https:\/\/doi.org\/10.1002\/adhm.71082","archive":["Portico"],"relation":{},"ISSN":["2192-2640","2192-2659"],"issn-type":[{"value":"2192-2640","type":"print"},{"value":"2192-2659","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]},"assertion":[{"value":"2026-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71082"}}